Rizos E, Siafakas N, Skourti E, Papageorgiou C, Tsoporis J, Parker T H, Christodoulou D I, Spandidos D A, Katsantoni E, Zoumpourlis V
2nd Department of Psychiatry, National and Kapodistrian University of Athens, School of Medicine, University General Hospital 'ATTIKON', Athens 124 62, Greece.
Laboratory of Clinical Microbiology, National and Kapodistrian University of Athens, School of Medicine, University General Hospital 'ATTIKON', Athens 124 62, Greece.
Mol Med Rep. 2016 Dec;14(6):4942-4946. doi: 10.3892/mmr.2016.5853. Epub 2016 Oct 14.
Schizophrenia (SZ) and cancer (Ca) have a broad spectrum of clinical phenotypes and a complex biological background, implicating a large number of genetic and epigenetic factors. SZ is a chronic neurodevelopmental disorder signified by an increase in the expression of apoptotic molecular signals, whereas Ca is conversely characterized by an increase in appropriate molecular signaling that stimulates uncontrolled cell proliferation. The rather low risk of developing Ca in patients suffering from SZ is a hypothesis that is still under debate. Recent evidence has indicated that microRNAs (miRNAs or miRs), a large group of small non‑coding oligonoucleotides, may play a significant role in the development of Ca and major psychiatric disorders, such as SZ, bipolar disorder, autism spectrum disorders, suicidality and depression, through their interference with the expression of multiple genes. For instance, the possible role of let‑7, miR‑98 and miR‑183 as biomarkers for Ca and SZ was investigated in our previous research studies. Therefore, further investigations on the expression profiles of these regulatory, small RNA molecules and the molecular pathways through which they exert their control may provide a plausible explanation as to whether there is a correlation between psychiatric disorders and low risk of developing Ca.
精神分裂症（SZ）和癌症（Ca）具有广泛的临床表型和复杂的生物学背景，涉及大量遗传和表观遗传因素。SZ是一种慢性神经发育障碍，其特征是凋亡分子信号表达增加，而Ca则相反，其特征是刺激不受控制的细胞增殖的适当分子信号增加。SZ患者患Ca的风险相当低，这一假说仍在争论中。最近的证据表明，微小RNA（miRNA或miR）是一大类小的非编码寡核苷酸，可能通过干扰多个基因的表达，在Ca以及主要精神疾病（如SZ、双相情感障碍、自闭症谱系障碍、自杀倾向和抑郁症）的发生发展中发挥重要作用。例如，在我们之前的研究中，研究了let-7、miR-98和miR-183作为Ca和SZ生物标志物的可能作用。因此，进一步研究这些调节性小RNA分子的表达谱及其发挥调控作用的分子途径，可能为精神疾病与患Ca低风险之间是否存在关联提供合理的解释。
