Spaide Richard F, Suzuki Mihoko, Yannuzzi Lawrence A, Matet Alexandre, Behar-Cohen Francine
*Vitreous, Retina, Macula Consultants of New York, New York, New York; †The LuEster T. Mertz Retina Research Laboratory, New York, New York; and ‡Department of Ophthalmology, Fondation Asile des Aveugles, Jules-Gonin Eye Hospital, University of Lausanne, Lausanne, Switzerland.
Retina. 2017 Mar;37(3):424-435. doi: 10.1097/IAE.0000000000001344.
To evaluate multimodal imaging including volume-rendered angiographic and structural optical coherence tomography of macular telangiectasia Type 2 (MacTel2) for right-angle vein complexes, macular cavitations, and signs of deeper retinal vascular invasion.
Retrospective review of imaging performed in a community-based retinal referral center. The eyes were scanned using optical coherence tomography using split-spectrum amplitude-decorrelation techniques to derive flow information. These data were extracted and used to create volume-rendered images of the retinal vasculature with integrated structural information derived from the component optical coherence tomographic images.
There were 24 eyes of 16 patients who had a mean age of 61.8 years. Right-angle veins seemed in association with vascular proliferation external to the deep vascular plexus. The origin of a right-angle vein was surrounded by a stellate arrangement of radiating retinal vessels apparently caused by contraction of surrounding tissue in the temporal macula. Cavitations were found in the fovea and varied in size and configuration from one examination to the next. Many smaller cavitations, called microcavitations, were seen in the surrounding macula. Vascular invasion occurred into the subretinal space.
There are contractile features of the tissue in the temporal macula and the number, size, and temporal variations in the cavitations have not been in not mentioned in previous published descriptions of MacTel2. Vascular invasion of deeper layers occurred in the temporal macula through the outer nuclear layer. Volume-rendered angiographic and structural optical coherence tomography offers unprecedented ability to examine the vascular interrelationships their associations with cavitations in the macula.
评估多模态成像，包括对2型黄斑毛细血管扩张症（MacTel2）的容积再现血管造影和结构光学相干断层扫描，以观察直角静脉复合体、黄斑空洞以及视网膜深层血管侵犯迹象。
对一家社区视网膜转诊中心进行的成像检查进行回顾性分析。使用光学相干断层扫描，采用分裂光谱幅度去相关技术扫描眼睛以获取血流信息。提取这些数据并用于创建视网膜血管的容积再现图像，整合来自光学相干断层扫描组件图像的结构信息。
16例患者的24只眼睛，平均年龄61.8岁。直角静脉似乎与深层血管丛外部的血管增生有关。直角静脉的起源被放射状视网膜血管的星状排列所包围，这显然是由于颞侧黄斑周围组织收缩所致。在黄斑中心凹发现有空洞，每次检查时其大小和形态各不相同。在周围黄斑区可见许多较小的空洞，称为微空洞。血管侵入视网膜下间隙。
颞侧黄斑组织存在收缩特征，空洞的数量、大小和时间变化在以往发表的MacTel2描述中未曾提及。深层血管通过外核层侵入颞侧黄斑。容积再现血管造影和结构光学相干断层扫描提供了前所未有的能力来检查黄斑区血管的相互关系及其与空洞的关联。
