水通道蛋白4抗体血清阳性视神经炎患者甲状腺异常的检测
Detection of Thyroid Abnormalities in Aquaporin-4 Antibody-Seropositive Optic Neuritis Patients.
作者信息
Zhao Shuo, Zhou Huanfen, Peng Xudong, Tan Shaoying, Liu Zihao, Chen Tingjun, Xu Quangang, Wei Shihui
机构信息
Department of Ophthalmology (SZ), Beijing Hospital, Beijing, China; Department of Ophthalmology (HZ), The First Affiliated Hospital of Chinese People's Liberation Army General Hospital, Beijing, China; Department of Ophthalmology (ST, TC, QX, SW), The Chinese People's Liberation Army General Hospital, Beijing, China; Department of Health Care (XP), The Chinese People's Liberation Army General Staff Department Guard Bureau, Beijing, China; and Department of Ophthalmology (ZL), The Chinese Dongzhimen Hospital, Beijing, China.
出版信息
J Neuroophthalmol. 2017 Mar;37(1):24-29. doi: 10.1097/WNO.0000000000000454.
OBJECTIVE
This study retrospectively analyzed the frequency of anti-thyroid antibodies (ATAs) and thyroid disease in patients with optic neuritis (ON).
METHODS
Tests of serum thyroglobulin (TG) and thyroid peroxidase (TPO) antibodies and thyroid function were performed in 97 ON patients. Blood also was drawn to test for AQP4-Ab using cell-based and enzyme-linked immunosorbent assays. Comparisons of the frequencies of ATAs, thyroid diseases and thyroid function were performed based on AQP4-Ab status.
RESULTS
Seropositive AQP4-Ab was found in 47/97 (48.5%) patients. ATA was considered positive in 34/97 (35.1%) patients. The prevalence of ATA was two times higher (P = 0.019) in the AQP4-Ab+ group compared to the AQP4-Ab- group. AQP4-Ab+ ON patients exhibited lower FT3 (P = 0.006) and FT4 (P = 0.025) levels and a higher prevalence of definite Hashimoto thyroiditis (HT) (P = 0.005). Among AQP4-Ab+ patients, those with HT had a worse visual outcome than non-HT patients.
CONCLUSION
A high prevalence of ATAs and HT was found in AQP4-Ab+ ON patients, and AQP4-Ab+ patients with HT exhibited worse visual outcomes than non-HT patients.
目的
本研究回顾性分析视神经炎（ON）患者中抗甲状腺抗体（ATA）的频率及甲状腺疾病情况。
方法
对97例ON患者进行血清甲状腺球蛋白（TG）、甲状腺过氧化物酶（TPO）抗体及甲状腺功能检测。同时采集血液，采用基于细胞和酶联免疫吸附测定法检测水通道蛋白4抗体（AQP4-Ab）。根据AQP4-Ab状态对ATA频率、甲状腺疾病及甲状腺功能进行比较。
结果
97例患者中47例（48.5%）血清AQP4-Ab呈阳性。97例患者中34例（35.1%）ATA被认为呈阳性。与AQP4-Ab阴性组相比，AQP4-Ab阳性组ATA患病率高出两倍（P = 0.019）。AQP4-Ab阳性的ON患者FT3（P = 0.006）和FT4（P = 0.025）水平较低，确诊桥本甲状腺炎（HT）的患病率较高（P = 0.005）。在AQP4-Ab阳性患者中，患有HT的患者视力预后比未患HT的患者更差。
结论
AQP4-Ab阳性的ON患者中ATA和HT的患病率较高，且患有HT的AQP4-Ab阳性患者视力预后比未患HT的患者更差。
Zotero 插件