Department of Cardiovascular Surgery, University Heart Center, Hamburg, Germany; Department of Thoracic and Cardiovascular Surgery, Saarland University Medical Center, Homburg/Saar, Germany.
Department of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
J Thorac Cardiovasc Surg. 2016 Dec;152(6):1549-1556.e2. doi: 10.1016/j.jtcvs.2016.07.072. Epub 2016 Aug 30.
Physical and mental recovery are important factors to consider in the treatment of aortic valve disease, and the process of recovery is not well known. We investigated the course of physical and mental recovery directly after conventional aortic valve surgery.
In a longitudinal study, 60 patients undergoing elective aortic valve surgery were studied preoperatively and at intervals of 4 weeks after aortic valve surgery. The last measurement was taken 6 months postoperatively. Measurements included the 6-minute walk test and N-terminal pro-B-type natriuretic peptide. Mental recovery was assessed by the Short Form Health Survey and the Hospital Anxiety and Depression Scale. All parameters were compared with published healthy norms.
All parameters except for the anxiety score showed a significant decline after the first postoperative measurement at 1 week after aortic valve surgery. The baseline level was restored at 1 to 3 weeks (anxiety, depression, mental quality of life, Borg scale), 4 to 6 weeks (6-minute walk test, physical quality of life), and 9 weeks (N-terminal pro-B-type natriuretic peptide) after the first postoperative week. Significantly better values than preoperatively for the first time were reached at 2 to 3 weeks (anxiety, depression, mental quality of life), 5 weeks (6-minute walk test), 8 weeks (physical quality of life), and 12 weeks (N-terminal pro-B-type natriuretic peptide) after the first postoperative week. At 3 months postoperatively, significant improvements (P < .001) were seen in walk distance (+212 m), dyspnea (-1.11), physical (+12.38) and mental quality of life (+7.71), anxiety (-3.74), and depression (-3.62) compared with the first week postoperatively. At 6 months postoperatively, all parameters were significantly improved compared with preoperative data and, except for the N-terminal pro-B-type natriuretic peptide value, significantly better or equal compared with published healthy norms.
After conventional aortic valve surgery, the most pronounced recovery was seen in the first 6 weeks postoperatively. Physical quality of life and N-terminal pro-B-type natriuretic peptide required a prolonged time for a complete recovery.
身心恢复是主动脉瓣疾病治疗中需要考虑的重要因素,而恢复过程尚不清楚。我们直接研究了常规主动脉瓣手术后的身心恢复过程。
在一项纵向研究中,对 60 例行择期主动脉瓣手术的患者进行了术前和主动脉瓣手术后 4 周的间隔测量。最后一次测量是在术后 6 个月进行的。测量包括 6 分钟步行测试和 N 端脑利钠肽前体。采用简明健康调查量表和医院焦虑抑郁量表评估精神恢复情况。所有参数均与已发表的健康标准进行比较。
除焦虑评分外,所有参数在主动脉瓣手术后第一周的第一次术后测量后均显著下降。基线水平在术后 1 至 3 周(焦虑、抑郁、精神生活质量、Borg 量表)、4 至 6 周(6 分钟步行测试、身体生活质量)和术后 9 周(N 端脑利钠肽前体)恢复。术后第一周后,首次出现明显优于术前的数值,分别为术后 2 至 3 周(焦虑、抑郁、精神生活质量)、第 5 周(6 分钟步行测试)、第 8 周(身体生活质量)和第 12 周(N 端脑利钠肽前体)。术后 3 个月,与术后第一周相比,步行距离增加(+212m)、呼吸困难减轻(-1.11)、身体(+12.38)和精神生活质量(+7.71)、焦虑(-3.74)和抑郁(-3.62)均显著改善(P<0.001)。术后 6 个月,与术前数据相比,所有参数均有显著改善,除 N 端脑利钠肽前体值外,与已发表的健康标准相比,均有显著改善或相当。
在常规主动脉瓣手术后,术后前 6 周恢复最为明显。身体生活质量和 N 端脑利钠肽前体需要更长的时间才能完全恢复。