Takeda Akihiro, Watanabe Kazuko, Hayashi Shotaro, Imoto Sanae, Nakamura Hiromi
Department of Obstetrics and Gynecology, Gifu Prefectural Tajimi Hospital, Tajimi, Gifu, Japan.
Department of Diagnostic Pathology, Gifu Prefectural Tajimi Hospital, Tajimi, Gifu, Japan.
J Pediatr Adolesc Gynecol. 2017 Apr;30(2):251-255. doi: 10.1016/j.jpag.2016.10.005. Epub 2016 Oct 15.
Gynandroblastoma is an extremely rare ovarian sex cord tumor with malignant potential.
An 18-year-old adolescent experienced intermittent vaginal bleeding. A year later, a right adnexal mass with a heterogeneous imaging appearance was identified. Laparoendoscopic single-site ovarian tumorectomy was performed. A histopathological examination showed gynandroblastoma composed of juvenile granulosa and Sertoli-Leydig cells. Because the tumor was upstaged to stage Ic because of cyst rupture during surgery, three cycles of adjuvant chemotherapy with carboplatin and paclitaxel were added. Three years after surgery, no signs of recurrence have been noted.
The present findings can help clinicians make an accurate preoperative imaging diagnosis of gynandroblastoma with a juvenile granulosa cell component and plan an adequate treatment strategy for this rare, potentially malignant neoplasm.
两性母细胞瘤是一种极其罕见的具有恶性潜能的卵巢性索肿瘤。
一名18岁青少年出现间歇性阴道出血。一年后，发现右侧附件区有一个影像学表现不均匀的肿块。实施了腹腔镜单孔卵巢肿瘤切除术。组织病理学检查显示两性母细胞瘤由幼年型颗粒细胞和支持-莱迪希细胞组成。由于手术中囊肿破裂，肿瘤分期升为Ⅰc期，因此加用了三个周期的卡铂和紫杉醇辅助化疗。术后三年，未发现复发迹象。
目前的研究结果有助于临床医生对具有幼年型颗粒细胞成分的两性母细胞瘤进行准确的术前影像学诊断，并为这种罕见的潜在恶性肿瘤制定适当的治疗策略。
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