Janssen Marloes A M, Koopmans Peter P, Kessels Roy P C
Department of Medical Psychology 840, Radboud University Nijmegen Medical Center, P.O. box 9101, 6500 HB, Nijmegen, The Netherlands.
Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
AIDS Behav. 2017 Jun;21(6):1728-1734. doi: 10.1007/s10461-016-1583-7.
The objectives of the current study were to examine cognitive decline in relation to psychological wellbeing, HIV disease and treatment characteristics and baseline variables over a one-year period of time in a group of HIV-infected patients on long term cART with undetectable viral load in comparison to a HIV-negative control group. Eighty-two of 95 patients and 43 of 55 controls who completed a baseline assessment for the Art-NeCo study underwent a follow-up neuropsychological assessment. A repeated-measure general linear model analysis was performed to compare the performance at follow-up in comparison to baseline between the patients and controls. Reliable change indices were computed as a measure of significant change in cognitive function. Compared to controls, patients overall performed worse on the domain speed of information processing. In the patient group a worse performance at follow-up was present for the verbal fluency domain compared to the controls, in the absence of a baseline group difference. For the executive function domain, no group differences were found at follow-up, but the patients performed worse than the controls at baseline. We found that cognitive decline was related to more frequent use of recreational drugs and a somewhat heightened level of irritability and more somatic complaints at baseline. However, the decliners did not differ from the non-decliners on any of the HIV-related variables.
本研究的目的是，在一组长期接受抗逆转录病毒治疗（cART）且病毒载量不可检测的HIV感染患者中，与HIV阴性对照组相比，在一年时间内研究认知功能下降与心理健康、HIV疾病及治疗特征和基线变量之间的关系。参与Art-NeCo研究并完成基线评估的95例患者中的82例以及55例对照组中的43例接受了随访神经心理学评估。采用重复测量一般线性模型分析来比较患者和对照组随访时与基线时的表现。计算可靠变化指数作为认知功能显著变化的指标。与对照组相比，患者在信息处理速度领域的总体表现更差。在患者组中，与对照组相比，随访时言语流畅性领域表现更差，而基线时两组无差异。在执行功能领域，随访时未发现组间差异，但患者在基线时表现比对照组差。我们发现，认知功能下降与更频繁使用消遣性药物以及基线时易怒程度略有升高和更多躯体不适有关。然而，在任何与HIV相关的变量上，认知功能下降者与未下降者并无差异。
