Kopp Benjamin T, Ortega-García Juan Antonio, Sadreameli S Christy, Wellmerling Jack, Cormet-Boyaka Estelle, Thompson Rohan, McGrath-Morrow Sharon, Groner Judith A
Section of Pediatric Pulmonology, Nationwide Children's Hospital, Columbus, OH 43205, USA.
Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.
Int J Environ Res Public Health. 2016 Oct 12;13(10):1003. doi: 10.3390/ijerph13101003.
Secondhand smoke exposure (SHSe) has multiple adverse effects on lung function and growth, nutrition, and immune function in children; it is increasingly being recognized as an important modifier of disease severity for children with chronic diseases such as cystic fibrosis (CF). This review examines what is known regarding the prevalence of SHSe in CF, with the majority of reviewed studies utilizing parental-reporting of SHSe without an objective biomarker of exposure. A wide range of SHSe is reported in children with CF, but under-reporting is common in studies involving both reported and measured SHSe. Additionally, the impact of SHSe on respiratory and nutritional health is discussed, with potential decreases in long-term lung function, linear growth, and weight gain noted in CF children with SHSe. Immunologic function in children with CF and SHSe remains unknown. The impact of SHSe on cystic fibrosis transmembrane conductance regulator (CFTR) function is also examined, as reduced CFTR function may be a pathophysiologic consequence of SHSe in CF and could modulate therapeutic interventions. Finally, potential interventions for ongoing SHSe are delineated along with recommended future areas of study.
接触二手烟（SHSe）对儿童的肺功能、生长发育、营养状况和免疫功能有多种不良影响；它日益被认为是患有诸如囊性纤维化（CF）等慢性病儿童疾病严重程度的重要调节因素。本综述探讨了关于CF患者中SHSe患病率的已知情况，大多数综述研究采用父母报告的SHSe情况，而没有接触的客观生物标志物。CF患儿中报告的SHSe范围很广，但在涉及报告和测量的SHSe的研究中，漏报情况很常见。此外，还讨论了SHSe对呼吸和营养健康的影响，注意到患有SHSe的CF患儿长期肺功能、线性生长和体重增加可能会下降。CF合并SHSe患儿的免疫功能尚不清楚。还研究了SHSe对囊性纤维化跨膜传导调节因子（CFTR）功能的影响，因为CFTR功能降低可能是CF中SHSe的病理生理后果，并可能调节治疗干预措施。最后，阐述了针对持续SHSe的潜在干预措施以及推荐的未来研究领域。
