体重指数升高且接触二手烟的青少年的氧化应激
Oxidative Stress in Youth and Adolescents With Elevated Body Mass Index Exposed to Secondhand Smoke.
作者信息
Groner Judith A, Huang Hong, Eastman Nicholas, Lewis Luke, Joshi Mandar S, Schanbacher Brandon L, Nicholson Lisa, Bauer John A
机构信息
Nationwide Children's Hospital, Ohio State University College of Medicine, Columbus, OH; American Academy of Pediatrics, Julius B. Richmond Center of Excellence, Elk Grove Village, IL;
Department of Pediatrics, University of Kentucky College of Medicine, Lexington, KY;
出版信息
Nicotine Tob Res. 2016 Jul;18(7):1622-7. doi: 10.1093/ntr/ntw025. Epub 2016 Feb 22.
INTRODUCTION
Our objective was to investigate the relationships between secondhand smoke (SHS) exposure and oxidative stress in a group of youth and adolescents with elevated body mass index.
METHODS
Participants in this cross sectional study were healthy nonsmoking youth and adolescents ages 9 to 18 years old. Three-quarters of the participants were either overweight or obese. SHS exposure was determined by survey and hair nicotine level. Markers of oxidation were total antioxidant capacity and protein malondialdehyde adducts (MDA).
RESULTS
Ninety subjects were studied; adequate hair samples were available for 86. The mean hair nicotine level was 0.75ng/mg, the median was 0.58ng/mg and the range was 0.09-2.88ng/mg. There was a significant relationship between MDA and the three survey questions regarding smoke exposure ([mother smokes, r = 0.29, P = .006], [smoker lives in the home, r = 0.31, P = .004], and [number of smokers in the home, r = 0.36, P = .002]). There was a significant positive relationship between log-hair nicotine and MDA (Pearson r = 0.233, P = .031), which remained significant after controlling for age, sex, race, and method of insurance. No relationship was found between log-hair nicotine and total antioxidant capacity. However, there was a significant relationship between number of smokers in the home (r = 0.24, P = .042) and total antioxidant capacity.
CONCLUSIONS
We have demonstrated a significant positive relationship hair nicotine level and MDA in a group of youth with a high proportion of overweight/obese subjects.
IMPLICATIONS
We have shown a significant relationship between objectively measured SHS exposure and one marker of oxidative stress in a sample of youth and adolescents with a high proportion of overweight/obese subjects, and who were nonsmokers with relatively low tobacco exposure. This finding remains significant after controlling for age, sex, race, and type of medical insurance. Since the cardiovascular effects of SHS exposure are related to oxidative stress, this finding adds to our knowledge that the sequence of deleterious effects of tobacco exposure on the cardiovascular system begins long before clinical disease is evident.
引言
我们的目标是调查一组体重指数升高的青少年二手烟（SHS）暴露与氧化应激之间的关系。
方法
这项横断面研究的参与者为9至18岁的健康非吸烟青少年。四分之三的参与者超重或肥胖。通过调查和头发尼古丁水平确定二手烟暴露情况。氧化标志物为总抗氧化能力和蛋白质丙二醛加合物（MDA）。
结果
共研究了90名受试者；86名有足够的头发样本。头发尼古丁平均水平为0.75ng/mg，中位数为0.58ng/mg，范围为0.09 - 2.88ng/mg。MDA与三个关于烟雾暴露的调查问题之间存在显著关系（[母亲吸烟，r = 0.29，P = 0.006]，[家中有吸烟者，r = 0.31，P = 0.004]，以及[家中吸烟者数量，r = 0.36，P = 0.002]）。对数头发尼古丁与MDA之间存在显著正相关（Pearson r = 0.233，P = 0.031），在控制年龄、性别、种族和保险方式后仍显著。未发现对数头发尼古丁与总抗氧化能力之间存在关系。然而，家中吸烟者数量与总抗氧化能力之间存在显著关系（r = 0.24，P = 0.042）。
结论
我们在一组超重/肥胖受试者比例较高的青少年中证明了头发尼古丁水平与MDA之间存在显著正相关。
启示
我们在一组超重/肥胖受试者比例较高、非吸烟且烟草暴露相对较低的青少年样本中，表明客观测量的二手烟暴露与氧化应激的一个标志物之间存在显著关系。在控制年龄、性别、种族和医疗保险类型后，这一发现仍然显著。由于二手烟暴露对心血管的影响与氧化应激有关，这一发现增加了我们的认识，即烟草暴露对心血管系统的有害影响序列早在临床疾病明显之前就开始了。
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