Kapellen Thomas M, Reimann Rebecca, Kiess Wieland, Kostev Karel
J Pediatr Endocrinol Metab. 2016 Nov 1;29(11):1293-1297. doi: 10.1515/jpem-2016-0171.
The aim of this study was to analyze the prevalence of attention deficit hyperactivity disorder (ADHD) in children and adolescents with type 1 diabetes mellitus (T1DM) in Germany.
Two different representative German databases - IMS®-Disease Analyzer, a database that includes diagnoses as well as other information, and IMS®-LRx, a database that documents prescriptions - were used to conduct a retrospective analysis. We searched the LRx database for patients who received both insulin and ADHD-specific medication.
In 2014, 677,587 children and adolescents aged 0-18 years were treated by a pediatrician and documented in the Disease Analyzer database. Of these patients, 16,833 received the International Statistical Classification of Diseases and Related Health Problems (ICD-10) diagnosis of ADHD (2.5%) and 3668 patients were treated for T1DM (0.1%). Of these 3668 patients, a total of 153 children were also diagnosed with ADHD (4.2%; p<0.05). In the LRx database, the overall prevalence of children in Germany who received both drugs for the treatment of ADHD and insulin in 2014 amounted to 2.9%. Diagnosis of ADHD is 2.4-3.3 times more frequent in boys than in girls. The highest prevalence was seen in the age group of 12-15 years (3.5%) and the lowest in the age group of 6-11 years (2.5%).
Children with diabetes suffer from ADHD significantly more frequently than children without diabetes. The prevalence of medically treated children with ADHD and diabetes is similar to that documented in a recent report by the Barmer GEK health insurance body. However, it is possible that children with T1DM are much more frequently seen by medical care providers and are thus more likely to be evaluated and receive an appropriate diagnosis.
本研究旨在分析德国1型糖尿病(T1DM)儿童及青少年中注意力缺陷多动障碍(ADHD)的患病率。
使用两个不同的具有代表性的德国数据库——IMS®疾病分析器(一个包含诊断及其他信息的数据库)和IMS®-LRx(一个记录处方的数据库)进行回顾性分析。我们在LRx数据库中搜索同时接受胰岛素和ADHD特异性药物治疗的患者。
2014年,677,587名0至18岁的儿童及青少年由儿科医生进行治疗并记录在疾病分析器数据库中。在这些患者中,16,833人被诊断患有ADHD(国际疾病分类第十版,ICD - 10)(2.5%),3668名患者接受T1DM治疗(0.1%)。在这3668名患者中,共有153名儿童也被诊断患有ADHD(4.2%;p<0.05)。在LRx数据库中,2014年德国同时接受ADHD治疗药物和胰岛素治疗的儿童总体患病率为2.9%。ADHD在男孩中的诊断频率比女孩高2.4至3.3倍。患病率最高的年龄组为12至15岁(3.5%),最低的为6至11岁年龄组(2.5%)。
患有糖尿病的儿童患ADHD的频率明显高于无糖尿病的儿童。接受药物治疗的ADHD合并糖尿病儿童的患病率与最近巴默GEK健康保险公司报告中记录的患病率相似。然而,T1DM儿童可能更频繁地被医疗服务提供者诊治,因此更有可能接受评估并获得适当诊断。