Zhang-James Yanli, Draytsel Dan, Carguello Ben, Faraone Stephen V, Weinstock Ruth S
Department of Psychiatry and Behavioral Sciences, Norton College of Medicine, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA.
Norton College of Medicine, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA.
J Clin Med. 2025 May 21;14(10):3606. doi: 10.3390/jcm14103606.
to assess the association between attention-deficit/hyperactivity disorder (ADHD), type 1 diabetes mellitus (T1D), and cardiovascular comorbidities in adults. The Adult Self-Report Scale V1.1 (ASRS) for ADHD symptoms was electronically sent to 2069 adults with T1D. Cardiometabolic conditions, laboratory measurements, and PHQ-2/PHQ-9 depression scores were obtained from the electronic medical record. In total, 292 (14.1%) individuals responded and 279 consented to medical records extraction. The average age was 47.4 years (SD: ±18.9), 64.2% were women, 95.7% were non-Hispanic white, and the mean HbA1c level was 7.7% (±1.5%). Of 273 completing ASRS, 87 med ADHD criteria (ASRS positive, 31.9%), and 42 (15.4%) had an ADHD diagnosis or medication. Women had higher scores than men. ADHD symptoms decreased with age, but remained significantly higher than the general population levels. HbA1c levels were positively associated with the ASRS scores (Spearman's r = 0.28, < 0.0001). ASRS positive individuals had worse glycemic control (HbA1c ≥ 8.0%, adjusted OR 2.3, 95%CI: 1.3-4.1, < 0.0001) and higher PHQ-9 scores (10 ± 7.3 vs. 6.1 ± 6, χ = 9.2, = 0.002) than the ASRS negative group. No associations were found between ASRS scores and cardiometabolic diseases, or other laboratory or clinical measurements. Many adults with T1D exhibit undiagnosed ADHD symptoms, which correlate with poorer glycemic control and depression. Further research with larger samples is needed to investigate ADHD prevalence and impacts in this group.
评估成人注意力缺陷多动障碍（ADHD）、1型糖尿病（T1D）和心血管合并症之间的关联。用于评估ADHD症状的成人自陈量表V1.1（ASRS）通过电子方式发送给2069名患有T1D的成人。从电子病历中获取心脏代谢状况、实验室测量结果以及PHQ - 2/PHQ - 9抑郁评分。共有292名（14.1%）个体做出回应，其中279人同意提取病历。平均年龄为47.4岁（标准差：±18.9），64.2%为女性，95.7%为非西班牙裔白人，平均糖化血红蛋白（HbA1c）水平为7.7%（±1.5%）。在完成ASRS的273人中，87人符合ADHD标准（ASRS阳性，31.9%），42人（15.4%）有ADHD诊断或正在接受药物治疗。女性得分高于男性。ADHD症状随年龄增长而降低，但仍显著高于一般人群水平。HbA1c水平与ASRS评分呈正相关（斯皮尔曼相关系数r = 0.28，P < 0.0001）。与ASRS阴性组相比，ASRS阳性个体的血糖控制更差（HbA1c≥8.0%，校正比值比2.3，95%置信区间：1.3 - 4.1，P < 0.0001）且PHQ - 9得分更高（10 ± 7.3对6.1 ± 6，χ² = 9.2，P = 0.002）。未发现ASRS评分与心脏代谢疾病、或其他实验室或临床测量结果之间存在关联。许多患有T1D的成人表现出未被诊断的ADHD症状，这与较差的血糖控制和抑郁相关。需要对更大样本进行进一步研究，以调查该群体中ADHD的患病率及其影响。
