Mameli P, Giraudi D, Virdis A, Firinu C, Marini S, Marrosu P
Boll Soc Ital Biol Sper. 1989 May;65(5):391-8.
Since functional overload in pregnancy frequently induces the appearance of symptoms that could arouse suspicion of myocardiopathy, it is important to analyse and characterize all electrocardiographic modifications during a healthy subject's pregnancy. Variations of the mean electrical axis (A) of P, QRS and T waves were evaluated in 52 healthy volunteers, 17-37 years, during pregnancy. The A values were measured, in the frontal plane, at the end of both I and III quarter of pregnancy, using a method of scalar determination. The As in I and III quarters was compared with those observed in the post-partum (at 5th day) and statistical evaluations were performed (Student t-test for paired observations). In the I quarter the mean A was 40 +/- 3 degrees for P, 40 +/- 16 degrees for QRS and 32.5 +/- 9 degrees for T wave, whereas in the III quarter the mean A changed to 37 +/- 2 degrees for P, 34 +/- 18 degrees for QRS and 31 +/- 9 degrees for T. During pregnancy, all mean As significantly diverted to the left side, AP about 3 degrees, AQRS about 6 degrees and AT about 1.5 degrees. These results were also confirmed by analysis of A frequency distribution histograms. In the post-partum (5th day) the A resumed basal values (I quarter's values). These results show: i) the physiological range of AP, AQRS and AT, during pregnancy; ii) left deviation of all three As at the end of III quarter. It is possible to conclude that variation over this range, particularly for QRS, could give evidence of the onset of cardiopathy.
由于孕期功能负荷过重常引发一些可能让人怀疑患有心肌病的症状,因此分析和描述健康女性孕期所有的心电图变化很重要。我们对52名年龄在17至37岁的健康志愿者孕期的P、QRS和T波平均电轴(A)变化进行了评估。采用标量测定法,在孕期第一和第三季度末测量额面的A值。将第一和第三季度的A值与产后(第5天)观察到的A值进行比较,并进行统计学评估(配对观察的Student t检验)。在第一季度,P波平均A值为40±3度,QRS波为40±16度,T波为32.5±9度;而在第三季度,P波平均A值变为37±2度,QRS波为34±18度,T波为31±9度。孕期所有平均A值均显著向左偏移,P波约3度,QRS波约6度,T波约1.5度。A频率分布直方图分析也证实了这些结果。产后(第5天),A值恢复到基础值(第一季度的值)。这些结果表明:i)孕期P波、QRS波和T波平均电轴的生理范围;ii)第三季度末所有三个平均电轴均向左偏移。可以得出结论,在此范围内的变化,尤其是QRS波的变化,可能提示心脏病的发生。