Eriksson L, Frankenne F, Edèn S, Hennen G, Von Schoultz B
Department of Obstetrics and Gynecology, University Hospital, Umeå, Sweden.
Br J Obstet Gynaecol. 1989 Aug;96(8):949-53. doi: 10.1111/j.1471-0528.1989.tb03352.x.
Serum profiles of growth hormone (GH) were recorded for 24 h in women at different stages of normal pregnancy. Two monoclonal antibodies directed against different epitopes and unaffected by human placental lactogen were used in radioimmunoassays to distinguish the pituitary 22K-GH from the placental GH variant. The 'normal' episodic peak activity of GH in non-pregnant and first trimester pregnant women was dramatically changed into a continuous very stable secretion during late pregnancy. This change was first observed at 17 weeks gestation. It is concluded that during the second half of pregnancy, serum measurements of GH reflect a major contribution from a non-episodically secreted placental GH variant and a concomitant suppression of pituitary GH. This specific signal, i.e. a continuous GH secretion, may be an important regulator of maternal liver metabolism during pregnancy.
对处于正常孕期不同阶段的女性进行了24小时生长激素（GH）血清谱记录。在放射免疫分析中使用了两种针对不同表位且不受人胎盘催乳素影响的单克隆抗体，以区分垂体22K - GH和胎盘GH变体。非孕期和孕早期女性中GH的“正常”间歇性峰值活性在妊娠晚期显著转变为持续非常稳定的分泌。这种变化在妊娠17周时首次观察到。得出的结论是，在妊娠后半期，血清GH测量反映了非间歇性分泌的胎盘GH变体的主要贡献以及垂体GH的同时抑制。这种特定信号，即持续的GH分泌，可能是孕期母体肝脏代谢的重要调节因子。
