Eriksson L, Frankenne F, Edén S, Hennen G, von Schoultz B
Department of Obstetrics and Gynecology, University Hospital, Umeå, Sweden.
Acta Obstet Gynecol Scand. 1988;67(6):549-52. doi: 10.3109/00016348809029868.
Serum profiles of growth hormone (GH), hPL and hCG were recorded in 5 pregnant women during termination of pregnancy at cesarean section and legal abortion. Two monoclonal antibodies directed against different epitopes on the GH molecule were used to distinguish the pituitary 22K-GH from the placental GH variant. After placental removal at cesarean section, a rapid fall in GH as well as in hPL and hCG concentrations was recorded. On the other hand GH levels were unaffected when early pregnancy was terminated by legal abortion. The importance of an intact placental function for the maintenance of high GH levels lends further support to the concept that a placental GH variant is produced during late pregnancy.
在剖宫产和合法堕胎终止妊娠期间，记录了5名孕妇的生长激素（GH）、人胎盘催乳素（hPL）和人绒毛膜促性腺激素（hCG）的血清谱。使用两种针对GH分子上不同表位的单克隆抗体来区分垂体22K - GH和胎盘GH变体。剖宫产取出胎盘后，记录到GH以及hPL和hCG浓度迅速下降。另一方面，合法堕胎终止早期妊娠时，GH水平未受影响。完整的胎盘功能对于维持高GH水平的重要性进一步支持了妊娠晚期产生胎盘GH变体的概念。
