Wang Qing, Liu Wenwen, Wu Yili, Ma Yan, Zhao Guiqiu
Department of Ophthalmology, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Department of Epidemiology and Health Statistics, Medical College of Qingdao University, Qingdao, Shandong, China.
Clin Exp Optom. 2017 May;100(3):250-254. doi: 10.1111/cxo.12485. Epub 2016 Oct 18.
An investigation was carried out to find the distribution of central corneal thickness (CCT) and the association between CCT and ocular factors in a cohort of myopic Chinese adults who underwent laser refractive surgery.
Medical records of 1,190 subjects (754 males) aged from 18 to 44 years (21.5 ± 3.5 years for males and 24.9 ± 5.5 years for females) undergoing myopic refractive surgery were filtered and analysed. Each parameter was stratified by gender and eye, respectively. Multi-linear and linear regressions were used to analyse the effect of intraocular pressure (IOP), period of contact lens wearing, gender, age, refractive error, mean corneal curvature (K) and ocular high-order aberration at 5.0-mm zone on CCT.
The mean CCT was 539.2 ± 37.8 µm in the whole study population. Males had greater CCT than females (p < 0.001), while females had greater K than males (p < 0.001). There was no difference in IOP, ocular cylinder or higher-order aberrations between genders. No interocular difference was identified either in IOP or K. Multi-linear regression model revealed that only gender, IOP and K were correlated with CCT (standardised coefficients of right eye are -0.101, p = 0.001 for gender, 0.231, p < 0.001 for IOP and -0.080, p = 0.009 for K; standardised coefficients of left eye are -0.090, p = 0.002 for gender, 0.310, p < 0.001 for IOP and -0.076, p = 0.015 for K).
In a population of myopic candidates for laser refractive surgery, only gender, IOP and K were correlated with CCT.
对一组接受激光屈光手术的近视成年中国人进行了一项调查，以了解中央角膜厚度（CCT）的分布情况以及CCT与眼部因素之间的关联。
筛选并分析了1190名年龄在18至44岁之间（男性21.5±3.5岁，女性24.9±5.5岁）接受近视屈光手术患者的病历。每个参数分别按性别和眼别进行分层。采用多元线性回归和线性回归分析眼压（IOP）、佩戴隐形眼镜时间、性别、年龄、屈光不正、平均角膜曲率（K）以及5.0毫米区域的眼高阶像差对CCT的影响。
整个研究人群的平均CCT为539.2±37.8微米。男性的CCT大于女性（p<0.001），而女性的K大于男性（p<0.001）。性别之间在眼压、柱镜度数或高阶像差方面无差异。眼压或K在两眼之间也未发现差异。多元线性回归模型显示，仅性别、眼压和K与CCT相关（右眼的标准化系数分别为：性别-0.101，p = 0.001；眼压0.231，p<0.001；K -0.080，p = 0.009；左眼的标准化系数分别为：性别-0.090，p = 0.002；眼压0.310，p<0.001；K -0.076，p = 0.015）。
在接受激光屈光手术的近视人群中，仅性别、眼压和K与CCT相关。
