Kobayashi Ryota, Hashimoto Yuto, Hatakeyama Hiroyuki, Okamoto Takanobu
Graduate School of Health and Sport Science, Nippon Sport Science University, Tokyo, Japan.
Department of Exercise Physiology, Nippon Sport Science University, Tokyo, Japan.
Clin Physiol Funct Imaging. 2018 Jan;38(1):138-144. doi: 10.1111/cpf.12395. Epub 2016 Oct 18.
Arterial stiffness increases after glucose ingestion. Acute low- and moderate-intensity aerobic exercise decreases arterial stiffness. However, the acute effects of 30 min of cycling at low- and moderate-intensity [25% (LE trial) and 65% (ME trial) peak oxygen uptake, respectively] on arterial stiffness at 30, 60 and 120 min of a postexercise glucose ingestion. Ten healthy young men (age, 22·4 ± 0·5 years) performed LE and ME trials on separate days in a randomized controlled crossover fashion. Carotid-femoral (aortic) pulse wave velocity (PWV), femoral-ankle (leg) PWV, carotid augmentation index (AIx) and carotid blood pressure (BP) (applanation tonometry), brachial and ankle BP (oscillometric device), heart rate (HR) (electrocardiography), blood glucose (UV-hexokinase method) and blood insulin (CLEIA method) levels were measured at before (baseline) and at 30, 60 and 120 min after the 75-g OGTT. Leg PWV, ankle pulse pressure and BG levels significantly increased from baseline after the 75-g OGTT in the LE trial (P<0·05), but not in the ME trial. Insulin levels and HR significantly increased from baseline after the 75-g OGTT in both trials (P<0·05). Aortic PWV, carotid AIx, brachial BP and carotid BP did not change from baseline after the 75-g OGTT in both trials. The present findings indicate that aerobic exercise at moderate intensity before glucose ingestion suppresses increases leg arterial stiffness after glucose ingestion.
摄入葡萄糖后动脉僵硬度增加。急性低强度和中等强度有氧运动可降低动脉僵硬度。然而，在摄入葡萄糖后30、60和120分钟时，分别以低强度[25%（低强度试验）和65%（中等强度试验）峰值摄氧量]进行30分钟骑行对动脉僵硬度的急性影响。10名健康年轻男性（年龄，22.4±0.5岁）以随机对照交叉方式在不同日期进行低强度和中等强度试验。在75克口服葡萄糖耐量试验（OGTT）前（基线）以及试验后30、60和120分钟测量颈股（主动脉）脉搏波速度（PWV）、股踝（腿部）PWV、颈动脉增强指数（AIx）和颈动脉血压（BP）（压平式眼压计）、肱动脉和踝部BP（示波装置）、心率（HR）（心电图）、血糖（紫外-己糖激酶法）和血胰岛素（化学发光免疫分析方法）水平。在低强度试验中，75克OGTT后腿部PWV、踝部脉压和血糖水平较基线显著升高（P<0.05），但在中等强度试验中未出现此情况。在两项试验中，75克OGTT后胰岛素水平和HR均较基线显著升高（P<0.05）。在两项试验中，75克OGTT后主动脉PWV、颈动脉AIx、肱动脉BP和颈动脉BP较基线均无变化。目前的研究结果表明，在摄入葡萄糖前进行中等强度有氧运动可抑制摄入葡萄糖后腿部动脉僵硬度的增加。
