Nikou G C, Yiangou Y, Chrysanthou B J, Domin J, Bloom S R
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Biosci Rep. 1989 Jun;9(3):369-74. doi: 10.1007/BF01114690.
The effect of peptide histidine valine-42 (PHV-42) on gastric acid secretion was studied in man. PHV-42 was infused into 5 healthy volunteers at a dose of 10 pmol/kg/min. This dose caused a significant stimulation of basal gastric acid and potassium output. There were no significant changes in circulating gastrin throughout the infusion. In 2 subjects with a background of submaximal pentagastrin stimulation, PHV-42 infusion at the same dose did not alter acid secretion in either subject. The previous observation that PHV-42 is found particularly in the stomach and the new finding that it stimulates basal gastric secretion suggest the possibility that PHV-42 could have a role in local control of acid secretion.
研究了肽组氨酸缬氨酸 -42（PHV -42）对人体胃酸分泌的影响。以10 pmol/kg/分钟的剂量向5名健康志愿者输注PHV -42。该剂量显著刺激了基础胃酸和钾的分泌。在整个输注过程中，循环胃泌素没有显著变化。在2名接受次最大剂量五肽胃泌素刺激的受试者中，以相同剂量输注PHV -42对两名受试者的胃酸分泌均无改变。先前观察到PHV -42特别存在于胃中，以及它能刺激基础胃酸分泌这一新发现，提示PHV -42可能在胃酸分泌的局部调节中发挥作用。
