Lynn W A, Dixon C M, Yiangou Y, Bloom S R, Ind P W
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, U.K.
Regul Pept. 1990 Jul 30;29(2-3):251-6. doi: 10.1016/0167-0115(90)90087-d.
Peptide histidine valine (PHV) is a 42 amino acid polypeptide closely related to the neuropeptides VIP, PHI and PHM. We have performed a placebo-controlled, double-blind study to assess the hypothesis that the cardiovascular response to PHV infusion may be mediated via the sympathetic nervous system. Four subjects received atenolol or matched placebo 90 min prior to a controlled incremental infusion of PHV, with monitoring of heart rate, blood pressure and skin temperature. Following placebo all subjects showed a dose-related increase in heart rate and skin temperature with no effect on blood pressure during PHV infusion. beta-Blockade had no effect on skin temperature response. Pre-treatment with atenolol reduced the resting blood pressure and the maximum heart rate achieved, but did not affect the percentage increase in heart rate during PHV infusion. This suggests that the action of PHV does not involve beta-receptors. The lack of effect of PHV infusion on blood pressure, despite tachycardia and marked cutaneous vasodilatation, implies that PHV has a different effect on the resistance vessels from that of other peptides such as VIP.
肽组氨酸缬氨酸（PHV）是一种由42个氨基酸组成的多肽，与神经肽血管活性肠肽（VIP）、肽组异亮氨酸（PHI）和肽组甲硫氨酸（PHM）密切相关。我们进行了一项安慰剂对照的双盲研究，以评估PHV输注引起的心血管反应可能通过交感神经系统介导这一假说。4名受试者在控制性递增输注PHV前90分钟接受阿替洛尔或匹配的安慰剂，并监测心率、血压和皮肤温度。在给予安慰剂后，所有受试者在输注PHV期间心率和皮肤温度均呈剂量依赖性增加，而对血压无影响。β受体阻滞剂对皮肤温度反应无影响。阿替洛尔预处理可降低静息血压和达到的最大心率，但不影响PHV输注期间心率的增加百分比。这表明PHV的作用不涉及β受体。尽管出现心动过速和明显的皮肤血管扩张，但PHV输注对血压无影响，这意味着PHV对阻力血管的作用与VIP等其他肽不同。
