人体中血管活性肠肽的输注：药代动力学及对胃酸分泌的影响。

Infusion of vasoactive intestinal polypeptide in man: pharmacokinetics and effect on gastric acid secretion.

作者信息

Holm-Bentzen M, Christiansen J, Petersen B, Fahrenkrug J, Schultz A, Kirkegaard P

机构信息

Dept. of Surgery D, Glostrup Hospital, University of Copenhagen, Denmark.

出版信息

Scand J Gastroenterol. 1981 Apr;16(3):429-32. doi: 10.3109/00365528109181992.

DOI:10.3109/00365528109181992

PMID:16435487

Abstract

Elimination and effect on acid secretion of vasoactive intestinal polypeptide (VIP) were studied in six healthy volunteers. On a background infusion of pentagastrin, 100 ng/kg-h, VIP was administered as stepwise intravenous infusions in doses of 0.5, 0.9, and 2.7 micro/g/kg-h, each dose being give for 1 h. Mean plasma VIP concentrations rose from 5.7 pmol/l to 28, 106 and 336 pmol/l during the VIP infusions. No significant changes in acid secretion occurred during VIP infusion as compared to infusion of pentagastrin alone, and no duodeno-gastric reflux was registered. Serum gastrin concentrations were unaltered during VIP infusion. Elimination of VIP was bi-exponential with half-lives of 2 and 21 min, respectively. Metabolic clearance rate was 42 ml/kg-min and the estimated volume of distribution 135 ml/kg.

摘要

在6名健康志愿者中研究了血管活性肠肽（VIP）的消除及其对胃酸分泌的影响。在以100 ng/kg-h的速度持续输注五肽胃泌素的基础上，以0.5、0.9和2.7 μg/kg-h的剂量逐步静脉输注VIP，每个剂量输注1小时。在输注VIP期间，血浆VIP平均浓度从5.7 pmol/l升至28、106和336 pmol/l。与单独输注五肽胃泌素相比，输注VIP期间胃酸分泌无显著变化，且未记录到十二指肠-胃反流。输注VIP期间血清胃泌素浓度未改变。VIP的消除呈双指数型，半衰期分别为2分钟和21分钟。代谢清除率为42 ml/kg-min，估计分布容积为135 ml/kg。