Che H-L, Kanthimathi M S, Loganathan R, Yuen K H, Tan A T B, Selvaduray K R, Nesaretnam K, Teng K-T
Nutrition Unit, Division of Product Development and Advisory Services, Malaysian Palm Oil Board, Kajang, Malaysia.
Department of Molecular Medicine, University of Malaya Centre for Proteomics Research (UMCPR), Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Eur J Clin Nutr. 2017 Jan;71(1):107-114. doi: 10.1038/ejcn.2016.200. Epub 2016 Oct 19.
BACKGROUND/OBJECTIVES: Evidence shows that tocotrienols potentially reverse various chronic disease progressions caused by the metabolic syndrome. We aimed to investigate the acute effects of a single-dose supplementation of gamma and delta tocotrienols (γδ-T3, 1:4 ratio) compared with those in placebo on the insulinemic, anti-inflammatory and anti-thrombogenic responses in metabolic syndrome subjects.
SUBJECTS/METHODS: Thirty metabolic syndrome subjects (15 men and 15 women) were recruited to a randomized, double-blinded and crossover study. The subjects were administered a single dose of 200 mg or 400 mg γδ-T3 emulsions or placebo incorporated into a glass of strawberry-flavored milkshake, consumed together with a high-fat muffin. Blood samples were collected at 0, 5, 15, 30, 60, 90, 120, 180, 240, 300 and 360 min after meal intake.
Plasma vitamin E levels reflected the absorption of γδ-T3 after treatments. Postprandial changes in serum C-peptide, serum insulin, plasma glucose, triacylglycerol, non-esterified fatty acid and adiponectin did not differ between treatments, with women displaying delayed increase in the aforementioned markers. No significant difference between treatments was observed for plasma cytokines (interleukin-1 beta, interleukin-6 and tumor necrosis factor alpha) and thrombogenic markers (plasminogen activator inhibitor type 1 and D-dimer).
Supplementation of a single dose of γδ-T3 did not change the insulinemic, anti-inflammatory and anti-thrombogenic responses in metabolic syndrome subjects.
背景/目的：有证据表明，生育三烯酚可能逆转由代谢综合征引起的各种慢性疾病进展。我们旨在研究单剂量补充γ-和δ-生育三烯酚（γδ-T3，比例为1:4）与安慰剂相比，对代谢综合征受试者的胰岛素、抗炎和抗血栓形成反应的急性影响。
受试者/方法：招募了30名代谢综合征受试者（15名男性和15名女性），进行一项随机、双盲和交叉研究。受试者服用单剂量200毫克或400毫克γδ-T3乳剂或安慰剂，将其混入一杯草莓味奶昔中，并与一个高脂松饼一起食用。在进食后0、5、15、30、60、90、120、180、240、300和360分钟采集血样。
血浆维生素E水平反映了治疗后γδ-T3的吸收情况。各治疗组之间餐后血清C肽、血清胰岛素、血浆葡萄糖、三酰甘油、非酯化脂肪酸和脂联素的变化无差异，女性上述指标的升高出现延迟。各治疗组之间血浆细胞因子（白细胞介素-1β、白细胞介素-6和肿瘤坏死因子α）和血栓形成标志物（纤溶酶原激活物抑制剂1型和D-二聚体）无显著差异。
单剂量补充γδ-T3不会改变代谢综合征受试者的胰岛素、抗炎和抗血栓形成反应。
