School of Biomedical Sciences, The University of Queensland, Brisbane 4072, Australia.
Nutrients. 2012 Oct 22;4(10):1527-41. doi: 10.3390/nu4101527.
Tocotrienols have been reported to improve lipid profiles, reduce atherosclerotic lesions, decrease blood glucose and glycated haemoglobin concentrations, normalise blood pressure in vivo and inhibit adipogenesis in vitro, yet their role in the metabolic syndrome has not been investigated. In this study, we investigated the effects of palm tocotrienol-rich fraction (TRF) on high carbohydrate, high fat diet-induced metabolic, cardiovascular and liver dysfunction in rats. Rats fed a high carbohydrate, high fat diet for 16 weeks developed abdominal obesity, hypertension, impaired glucose and insulin tolerance with increased ventricular stiffness, lower systolic function and reduced liver function. TRF treatment improved ventricular function, attenuated cardiac stiffness and hypertension, and improved glucose and insulin tolerance, with reduced left ventricular collagen deposition and inflammatory cell infiltration. TRF improved liver structure and function with reduced plasma liver enzymes, inflammatory cell infiltration, fat vacuoles and balloon hepatocytes. TRF reduced plasma free fatty acid and triglyceride concentrations but only omental fat deposition was decreased in the abdomen. These results suggest that tocotrienols protect the heart and liver, and improve plasma glucose and lipid profiles with minimal changes in abdominal obesity in this model of human metabolic syndrome.
生育三烯酚已被报道可改善血脂谱、减少动脉粥样硬化病变、降低血糖和糖化血红蛋白浓度、体内降低血压和体外抑制脂肪生成，但它们在代谢综合征中的作用尚未得到研究。在这项研究中，我们研究了富含棕榈生育三烯酚的馏分（TRF）对高碳水化合物、高脂肪饮食诱导的大鼠代谢、心血管和肝功能障碍的影响。用高碳水化合物、高脂肪饮食喂养 16 周的大鼠会发展为腹部肥胖、高血压、葡萄糖和胰岛素耐量受损，心室僵硬度增加、收缩功能降低和肝功能下降。TRF 治疗可改善心室功能，减轻心脏僵硬和高血压，并改善葡萄糖和胰岛素耐量，减少左心室胶原沉积和炎症细胞浸润。TRF 改善了肝脏结构和功能，降低了血浆肝酶、炎症细胞浸润、脂肪空泡和气球样肝细胞的数量。TRF 降低了血浆游离脂肪酸和甘油三酯浓度，但仅减少了腹部的网膜脂肪沉积。这些结果表明，生育三烯酚可保护心脏和肝脏，并改善血浆葡萄糖和脂质谱，同时在该人类代谢综合征模型中对腹部肥胖的改变最小。
