Duncan Andrew J E, Dudovitz Roxanne L, Dudovitz Shawna J, Stojaković Jelena, Mariappan S V Santhana, MacGillivray Leonard R
Department of Chemistry, University of Iowa, Iowa City, IA 52242-1294, USA.
Chem Commun (Camb). 2016 Nov 18;52(89):13109-13111. doi: 10.1039/c6cc06570h. Epub 2016 Oct 19.
We describe a [2+2] cross-photocycloaddition of the anticancer drug 5-fluorouracil in the solid state that proceeds regioselectively and in quantitative yield. The photocycloaddition occurs in a cocrystal with trans-2,2'-bis(pyridyl)ethylene.
我们描述了抗癌药物5-氟尿嘧啶在固态下的[2+2]交叉光环加成反应，该反应具有区域选择性且产率定量。光环加成反应发生在与反式-2,2'-双（吡啶基）乙烯形成的共晶中。
