Khandelwal S K, Sagar R S, Saxena S
Department of Psychiatry, All India Institute of Medical Sciences, New Delhi.
Br J Psychiatry. 1989 Jan;154:114-6. doi: 10.1192/bjp.154.1.114.
Although initially considered safe for the foetus, lithium has been shown to have teratogenic effects if used during the first trimester of pregnancy. Its use is also associated with a higher than expected frequency of still births and perinatal deaths. Our patient, in whom lithium prophylaxis was considered essential for clinical and social reasons, continued to take lithium without medical supervision throughout her pregnancy and had a still birth. We suggest avoiding the use of lithium at least during the first trimester of pregnancy.
尽管锂最初被认为对胎儿是安全的，但现已表明，如果在怀孕的头三个月使用，锂具有致畸作用。其使用还与高于预期的死产和围产期死亡频率相关。我们的患者，出于临床和社会原因，锂预防被认为是必不可少的，在整个怀孕期间未经医学监督继续服用锂，并出现了死产。我们建议至少在怀孕的头三个月避免使用锂。
