Glińska-Suchocka K, Orłowska A, Kubiak K, Spużak J, Jankowski M
Pol J Vet Sci. 2016 Sep 1;19(3):647-649. doi: 10.1515/pjvs-2016-0081.
The aim of this study was to assess whether the serum levels of the 7S fragment of type IV collagen may aid in diagnosing liver fibrosis in dogs. The study was carried out on 20 dogs with liver disease. Serum levels of the 7S fragment of type IV collagen were measured in all dogs. The analysis showed that healthy dogs and dogs with type 1, 2 and 3 liver fibrosis had low serum concentrations of the 7S fragment of type IV collagen compared to dogs with type 4 liver fibrosis. The study revealed that the assessment of serum levels of the 7S fragment of type IV collagen is useful in the diagnosis of advanced liver fibrosis and cirrhosis.
本研究的目的是评估IV型胶原7S片段的血清水平是否有助于诊断犬肝纤维化。该研究对20只患有肝脏疾病的犬进行。测定了所有犬IV型胶原7S片段的血清水平。分析表明，与患有4型肝纤维化的犬相比，健康犬以及患有1、2和3型肝纤维化的犬IV型胶原7S片段的血清浓度较低。该研究表明，评估IV型胶原7S片段的血清水平有助于诊断晚期肝纤维化和肝硬化。
