Glińska-Suchocka K, Orłowska A, Jankowski M, Kubiak K, Spużak J
Pol J Vet Sci. 2016;19(2):365-9. doi: 10.1515/pjvs-2016-0045.
The aim of the study was to evaluate the serum concentration of the type III procollagen aminopeptide in dogs, and to assess its utility in the diagnosis of liver fibrosis. The study was carried out on 20 dogs of different breeds and of both genders, between 7 and 15 years old. Based on the results of the histopathological examination and the evaluation of the degree of liver fibrosis, the dogs were divided into five groups. The mean serum PIIINP concentration in the group of dogs with stage 1 and 2 liver fibrosis (groups 2 and 3) was five-fold higher than in healthy dogs (group 1). In turn, the mean PIIINP concentration in the group of dogs with stage 3 (group 4) and stage 4 (group 5) fibrosis was 10-fold higher than that of the control group (group 1). Based on the results, we found that the serum PIIINP concentration correlated with the degree of liver fibrosis, assessed based on a histopathological examination. Therefore, PIIINP serum concentration tests may be a promising non-invasive diagnostic technique that could be used in veterinary hepatology to assess the degree of liver fibrosis.
本研究的目的是评估犬血清中III型前胶原氨基肽的浓度，并评估其在肝纤维化诊断中的效用。该研究对20只年龄在7至15岁之间、不同品种和性别的犬进行。根据组织病理学检查结果和肝纤维化程度评估，将这些犬分为五组。1期和2期肝纤维化犬组（第2组和第3组）的血清PIIINP平均浓度比健康犬组（第1组）高五倍。而3期（第4组）和4期（第5组）纤维化犬组的PIIINP平均浓度比对照组（第1组）高十倍。基于这些结果，我们发现血清PIIINP浓度与基于组织病理学检查评估的肝纤维化程度相关。因此，PIIINP血清浓度检测可能是一种有前景的非侵入性诊断技术，可用于兽医肝脏病学中评估肝纤维化程度。
