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磷脂酰肌醇-4,5-二磷酸3-激酶信号传导在囊泡运输中的作用

Role of phosphatidylinositol-4,5-bisphosphate 3-kinase signaling in vesicular trafficking.

作者信息

Bhattacharya Sayak, McElhanon Kevin E, Gushchina Liubov V, Weisleder Noah

机构信息

Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, 473 W. 12th Ave., Columbus, OH 43210-1252, United States.

Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, 473 W. 12th Ave., Columbus, OH 43210-1252, United States.

出版信息

Life Sci. 2016 Dec 15;167:39-45. doi: 10.1016/j.lfs.2016.10.018. Epub 2016 Oct 17.

DOI:10.1016/j.lfs.2016.10.018
PMID:27760304
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5204450/
Abstract

Phosphatidylinositol-4,5-bisphosphate 3-kinases (PI3Ks) are regulatory enzymes involved in the generation of lipid species that modulate cellular signaling pathways through downstream effectors to influence a variety of cellular functions. Years of intensive study of PI3Ks have produced a significant body of literature in many areas, including that PI3K can mediate intracellular vesicular trafficking and through these actions contribute to a number of important physiological functions. This review focuses on the crucial roles that PI3K and AKT, a major downstream partner of PI3K, play in the regulation of vesicle trafficking during various forms of vesicular endocytosis and exocytosis.

摘要

磷脂酰肌醇-4,5-二磷酸3-激酶（PI3Ks）是一类参与脂质生成的调节酶，这些脂质通过下游效应器调节细胞信号通路，进而影响多种细胞功能。多年来对PI3Ks的深入研究在许多领域产生了大量文献，包括PI3K可介导细胞内囊泡运输，并通过这些作用促成许多重要的生理功能。本综述重点关注PI3K及其主要下游伙伴AKT在各种形式的囊泡内吞作用和外排作用过程中对囊泡运输调节所起的关键作用。

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