Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241, PR China.
Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241, PR China.
Biomaterials. 2017 Jan;112:133-140. doi: 10.1016/j.biomaterials.2016.10.015. Epub 2016 Oct 11.
The development of thermo-degradable hydrogels is of great importance in drug delivery. However, it still remains a huge challenge to prepare thermo-degradable hydrogels with inherent degradation, reproducible, repeated and tunable dosing. Here, we reported a thermo-degradable hydrogel that is rapidly degraded above 44 °C by a facile chemistry. Besides thermo-degradability, the hydrogel also undergoes rapid photolysis with ultraviolet light. By embedding photothermal nanoparticles or upconversion nanoparticles into the gel, it can release the entrapped cargoes such as dyes, enzymes and anticancer drugs in an on-demand and dose-tunable fashion upon near-infrared light exposure. The smart hydrogel works well both in vitro and in vivo without involving sophisticated syntheses, and is well suited for clinical cancer therapy due to the high transparency and non-invasiveness features of near-infrared light.
温敏水凝胶在药物传递中具有重要意义。然而，要制备具有固有降解、可重复、可重复和可调剂量的温敏水凝胶仍然是一个巨大的挑战。在这里，我们报道了一种温敏水凝胶，通过一种简单的化学方法在 44°C 以上迅速降解。除了温敏性，水凝胶还可以通过紫外线快速光解。通过将光热纳米粒子或上转换纳米粒子嵌入凝胶中，它可以在近红外光照射下按需和剂量可调的方式释放染料、酶和抗癌药物等包封的货物。智能水凝胶在体外和体内都能很好地工作，不需要复杂的合成，由于近红外光的高透明度和非侵入性特点，非常适合临床癌症治疗。
