Ayoola Oluwagbemiga Oluwole, Bulus Peter, Loto Olabisi Morebisi, Idowu Bukunmi Michael
Department of Radiology, Obafemi Awolowo University Teaching Hospitals Complex, Ife, Nigeria.
Department of Obstetrics and Gynaecology, Obafemi Awolowo University Teaching Hospitals Complex, Ife, Nigeria.
J Obstet Gynaecol Res. 2016 Dec;42(12):1694-1698. doi: 10.1111/jog.13114. Epub 2016 Oct 20.
To determine the Doppler indices of the umbilical arteries in normal singleton pregnancy with a view to generating local reference ranges.
In this prospective, cross-sectional study, 400 pregnant women at 15-39 weeks' gestational age, with estimated fetal weight within the 10th and 90th percentile, no fetal malformation(s), and without any history of maternal medical disease, were recruited. Umbilical arteries were assessed on ultrasound, with the subjects in the supine position. Resistivity index (RI), pulsatility index (PI) and systolic/diastolic (S/D) ratio were recorded and analyzed.
All the umbilical arteries were paired; no single umbilical artery was seen. Mean RI, PI, and S/D ratio declined with gestational age, and decreased from 1.265 to 0.829, from 0.760 to 0.585 and from 4.068 to 2.365, respectively, from 15 to 39 weeks of gestation. With regard to correlation between gestational age and Doppler indices, r = - 0.598 for PI (P < 0.05), - 0.437 for RI (P < 0.05), and - 0.538 for S/D ratio (P < 0.05). Decline in the Doppler indices was progressive with gestational age.
A normogram of umbilical artery Doppler indices was constructed, which showed that the indices decreased with gestational age. These normative data could serve as reference ranges for evaluation of the umbilical artery circulation in this locality.
确定单胎正常妊娠脐动脉的多普勒指数，以建立本地参考范围。
在这项前瞻性横断面研究中，招募了400名孕龄为15 - 39周的孕妇，其估计胎儿体重在第10百分位数和第90百分位数之间，无胎儿畸形，且无任何母体疾病史。受试者取仰卧位，通过超声评估脐动脉。记录并分析阻力指数（RI）、搏动指数（PI）和收缩/舒张（S/D）比值。
所有脐动脉均为成对出现；未发现单脐动脉。平均RI、PI和S/D比值随孕周增加而下降，妊娠15至39周时，分别从1.265降至0.829、从0.760降至0.585以及从4.068降至2.365。关于孕周与多普勒指数的相关性，PI的r = - 0.598（P < 0.05），RI的r = - 0.437（P < 0.05），S/D比值的r = - 0.538（P < 0.05）。多普勒指数随孕周增加呈逐渐下降趋势。
构建了脐动脉多普勒指数的标准曲线，显示该指数随孕周增加而降低。这些标准数据可作为本地区评估脐动脉循环的参考范围。
