Adedo Abayomi Ayyuub, Arogundade Rasheed Ajani, Okunowo Adeyemi Adebola, Idowu Bukunmi Michael, Oduola-Owoo Latifat Tunrayo
Department of Radiology, Federal Medical Centre, Ebute-Metta, Lagos State, Nigeria.
Department of Radiation Biology, Radiotherapy, and Radiodiagnosis, College of Medicine, University of Lagos, Lagos State, Nigeria.
J West Afr Coll Surg. 2022 Apr-Jun;12(2):63-69. doi: 10.4103/jwas.jwas_63_22. Epub 2022 Aug 27.
This study compared the umbilical artery Doppler indices (UADI) in normal and foetal growth-restricted (FGR) foetuses to determine the relationship between the UADI and pregnancy outcomes.
This was a case-control study that recruited one hundred and eighty pregnant women comprising 90 with FGR pregnancies and 90 with normal pregnancies. Foetal biometric parameters and UADI were measured in all the participants. The UADI and clinical outcomes (preterm delivery, birth weight, perinatal death, etc.) of the normal and FGR foetuses were compared.
The mean estimated foetal weights of the FGR pregnancies (subjects) and normal pregnancies (controls) were 2.76 ± 0.66 kg and 3.62 ± 0.37 kg, respectively ( < 0.0001). The mean APGAR score at 5 min was 6.93 ± 1.72 for subjects and 8.03 ± 0.94 for controls ( < 0.0001). Abnormal umbilical artery Doppler waveforms were detected: decreased end-diastolic flow in 25 (27.8%), absent end-diastolic in 7 (7.8%) and reversed end-diastolic flow in 4 (4.4%) of the FGR pregnancies. There were 74 (82.2%) preterm deliveries among the subjects, while only 7 (7.8%) of the controls had preterm deliveries. Six deaths (two perinatal and four neonatal deaths) were recorded among the subjects, while no death occurred among the controls.
Foetuses with FGR showed significantly higher quantitative Doppler indices (increased RI, PI, SD ratio), and a higher prevalence of abnormal umbilical artery waveform pattern (qualitative) than the healthy foetuses (controls).
本研究比较了正常胎儿和胎儿生长受限（FGR）胎儿的脐动脉多普勒指数（UADI），以确定UADI与妊娠结局之间的关系。
这是一项病例对照研究，招募了180名孕妇，其中90名患有FGR妊娠，90名妊娠正常。对所有参与者测量胎儿生物测量参数和UADI。比较正常胎儿和FGR胎儿的UADI及临床结局（早产、出生体重、围产期死亡等）。
FGR妊娠（研究对象）和正常妊娠（对照组）的平均估计胎儿体重分别为2.76±0.66 kg和3.62±0.37 kg（<0.0001）。研究对象5分钟时的平均阿氏评分是6.93±1.72，对照组为8.03±0.94（<0.0001）。检测到FGR妊娠中有异常脐动脉多普勒波形：25例（27.8%）舒张末期血流减少，7例（7.8%）舒张末期血流消失，4例（4.4%）舒张末期血流反向。研究对象中有74例（82.2%）早产，而对照组只有7例（7.8%）早产。研究对象中有6例死亡（2例围产期死亡和4例新生儿死亡），而对照组无死亡发生。
与健康胎儿（对照组）相比，FGR胎儿的定量多普勒指数（阻力指数、搏动指数、标准差比值升高）显著更高，脐动脉波形异常模式（定性）的发生率也更高。
