He Wei, Huang Peng, Liu Dinghua, Zhong Lingling, Yu Rongbin, Li Jianan
Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
Department of Rehabilitation Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Int J Environ Res Public Health. 2016 Oct 17;13(10):1016. doi: 10.3390/ijerph13101016.
Base excision repair (BER) is the primary DNA repair system with the ability to fix base lesions caused by oxidative damage. Genetic variants influencing the BER pathway may affect the susceptibility and the outcomes of ischemic stroke. Here, we examined how single nucleotide polymorphisms (SNPs) associated with BER impact susceptibility and short-term recovery of ischemic stroke. We selected 320 ischemic stroke patients and 303 controls. Then we genotyped SNPs of rs4462560, rs12645561 and rs25487 in both groups. Polymorphism in rs25487 was significantly associated with reduced ischemic stroke (IS) risk (dominant model: OR = 0.53, 95% CI = 0.36-0.79, = 0.002), a milder initial stroke (dominant model: OR = 0.57, 95% CI = 0.33-0.98, = 0.043), and also a better short-term recovery (dominant model: OR = 0.57, 95% CI = 0.35-0.92, = 0.022). No association was observed in the other two SNPs. Our study suggests that the genetic variant of rs25487 may contribute to the etiology of ischemic stroke.
碱基切除修复（BER）是主要的DNA修复系统，具有修复由氧化损伤引起的碱基损伤的能力。影响BER途径的基因变异可能会影响缺血性中风的易感性和预后。在此，我们研究了与BER相关的单核苷酸多态性（SNP）如何影响缺血性中风的易感性和短期恢复情况。我们选取了320例缺血性中风患者和303名对照。然后对两组中的rs4462560、rs12645561和rs25487的SNP进行基因分型。rs25487的多态性与降低缺血性中风（IS）风险显著相关（显性模型：OR = 0.53，95%CI = 0.36 - 0.79，P = 0.002），初始中风症状较轻（显性模型：OR = 0.57，95%CI = 0.33 - 0.98，P = 0.043），并且短期恢复情况较好（显性模型：OR = 0.57，95%CI = 0.35 - 0.92，P = 0.022）。在其他两个SNP中未观察到关联。我们的研究表明，rs25487的基因变异可能与缺血性中风的病因有关。
