Presman Diego M, Hager Gordon L
a Laboratory of Receptor Biology and Gene Expression , National Cancer Institute, National Institutes of Health , Bethesda , MD , USA.
Transcription. 2017 Jan;8(1):32-39. doi: 10.1080/21541264.2016.1249045. Epub 2016 Oct 20.
It is widely accepted that the glucocorticoid receptor (GR), a ligand-regulated transcription factor that triggers anti-inflammatory responses, binds specific response elements as a homodimer. Here, we will discuss the original primary data that established this model and contrast it with a recent report characterizing the GR-DNA complex as a tetramer.
糖皮质激素受体（GR）是一种触发抗炎反应的配体调节转录因子，作为同二聚体结合特定反应元件，这一观点已被广泛接受。在此，我们将讨论建立该模型的原始基础数据，并将其与最近一篇将GR-DNA复合物表征为四聚体的报告进行对比。
