Kratofil Rachel M, Kubes Paul, Deniset Justin F
From the Department of Microbiology, Immunology, and Infectious Diseases (R.M.K., P.K.) and Department of Physiology and Pharmacology (P.K., J.F.D.), Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Canada.
Arterioscler Thromb Vasc Biol. 2017 Jan;37(1):35-42. doi: 10.1161/ATVBAHA.116.308198. Epub 2016 Oct 20.
Monocytes are circulating leukocytes important in both innate and adaptive immunity, primarily functioning in immune defense, inflammation, and tissue remodeling. There are 2 subsets of monocytes in mice (3 subsets in humans) that are mobilized from the bone marrow and recruited to sites of inflammation, where they carry out their respective functions in promoting inflammation or facilitating tissue repair. Our understanding of the fate of these monocyte subsets at the site of inflammation is constantly evolving. This brief review highlights the plasticity of monocyte subsets and their conversion during inflammation and injury.
单核细胞是循环白细胞，在固有免疫和适应性免疫中都很重要，主要在免疫防御、炎症和组织重塑中发挥作用。小鼠中有2个单核细胞亚群（人类中有3个亚群），它们从骨髓中动员出来并被募集到炎症部位，在那里它们在促进炎症或促进组织修复方面发挥各自的功能。我们对这些单核细胞亚群在炎症部位的命运的理解在不断发展。这篇简短的综述强调了单核细胞亚群的可塑性及其在炎症和损伤过程中的转化。
