Liu F X
First Hospital, Third Military Medical College.
Zhonghua Zhong Liu Za Zhi. 1989 Jan;11(1):16-8.
Nuclear DNA content was measured by microspectrophotometry in 15 biopsy specimens from patients with G-I smooth muscle tumors (3 leiomyomas and 12 leiomyosarcomas subdivided into 3 groups with 4 cases to each). The mean DNA value increased steadily as follows: leiomyomas (14.39 +/- 0.62 Au); leiomyosarcoma Grade I (19.78 +/- 2.39 Au); Leiomyosarcoma Grade II (26.39 +/- 1.60 Au); leiomyosarcoma Grade III (30.66 +/- 2.39 Au). The difference of DNA value in the 4 groups had statistical significance (P less than 0.05-0.01). These results suggest that microspectrophotometric measurement of nuclear DNA content may serve as an objective quantitative method for diagnosis of G-I tract smooth muscle tumors and classification of leiomyosarcoma.
采用显微分光光度法对15例胃肠道平滑肌肿瘤患者的活检标本进行核DNA含量测定（3例平滑肌瘤和12例平滑肌肉瘤，后者分为3组，每组4例）。平均DNA值呈稳步上升趋势，如下所示：平滑肌瘤（14.39 +/- 0.62吸光度单位）；Ⅰ级平滑肌肉瘤（19.78 +/- 2.39吸光度单位）；Ⅱ级平滑肌肉瘤（26.39 +/- 1.60吸光度单位）；Ⅲ级平滑肌肉瘤（30.66 +/- 2.39吸光度单位）。4组之间的DNA值差异具有统计学意义（P<0.05 - 0.01）。这些结果表明，核DNA含量的显微分光光度法测定可作为胃肠道平滑肌肿瘤诊断及平滑肌肉瘤分级的一种客观定量方法。
