Federspiel B H, Sobin L H, Helwig E B, Mikel U V, Bahr G F
Anal Quant Cytol Histol. 1987 May;9(2):105-14.
The difficulties in predicting the biologic behavior of gastrointestinal (GI) smooth-muscle tumors (leiomyomas and leiomyosarcomas) based on the usual criteria of malignancy are discussed. In order to evaluate the prognostic importance of the nuclear DNA content and nuclear dimensions, measurements were performed on Feulgen-stained sections of GI smooth-muscle tumors from 66 patients. The best discrimination between benign and malignant tumors was obtained by using DNA index and tumor size as descriptors in a linear discriminate analysis. This method separated 79% of the benign and 97% of the malignant smooth-muscle tumors. However, as with conventional criteria for malignancy, there remained a group of tumors close to the discriminating line with an indeterminate malignant potential. In an attempt to reduce the number of such indeterminate tumors, future studies will include the use of several descriptors in a multivariate analysis system and the application of flow cytometric studies to all tumors.
本文讨论了基于常规恶性标准预测胃肠道（GI）平滑肌肿瘤（平滑肌瘤和平滑肌肉瘤）生物学行为的困难。为了评估核DNA含量和核大小的预后重要性，对66例GI平滑肌肿瘤的福尔根染色切片进行了测量。在线性判别分析中，以DNA指数和肿瘤大小作为描述符，可对良性和恶性肿瘤进行最佳区分。该方法将79%的良性平滑肌肿瘤和97%的恶性平滑肌肿瘤区分开来。然而，与传统的恶性标准一样，仍有一组肿瘤接近判别线，其恶性潜能不确定。为了减少此类不确定肿瘤的数量，未来的研究将包括在多变量分析系统中使用多个描述符，以及对所有肿瘤应用流式细胞术研究。
