Kimura O, Kaibara N, Tamura H, Nishidoi H, Okamoto T, Koga S
Jpn J Surg. 1981;11(6):428-32. doi: 10.1007/BF02469026.
The nuclear DNA content of tumor cells in 5 leiomyomas, 4 leiomyoblastomas and 2 leiomyosarcomas of the stomach and 1 leiomyosarcoma of the small intestine was examined. From the viewpoint of nuclear DNA content, leiomyoblastoma was between leiomyoma and leiomyosarcoma. A definite difference in nuclear DNA content exists among leiomyoma, leiomyoblastoma and leiomyosarcoma, and percentage of nuclei with a DNA content of 3 times or 4 times over the basic chromosome content represented good indices for distinguishing between benign and malignant conditions. A diagnosis of leiomyocarcinoma may be more accurate when over 80% of the nuclei have DNA content values over 3 times of basic nuclear DNA content and when over 50% exhibit more than 4 times of basic content.
对5例胃平滑肌瘤、4例胃平滑肌瘤样瘤和2例胃平滑肌肉瘤以及1例小肠平滑肌肉瘤的肿瘤细胞的核DNA含量进行了检测。从核DNA含量的角度来看，平滑肌瘤样瘤介于平滑肌瘤和平滑肌肉瘤之间。平滑肌瘤、平滑肌瘤样瘤和平滑肌肉瘤之间在核DNA含量上存在明显差异，DNA含量为基本染色体含量3倍或4倍的细胞核百分比是区分良性和恶性情况的良好指标。当超过80%的细胞核DNA含量值超过基本核DNA含量的3倍且超过50%的细胞核表现出超过基本含量4倍时，平滑肌肉瘤的诊断可能更准确。
