Xu X Z
Jinan Military Hospital.
Zhonghua Zhong Liu Za Zhi. 1989 Jan;11(1):41-3.
Quantitative analysis of 10 cases of normal mucosa, 15 cases of villous adenoma and 20 cases of carcinoma of colon was studied by stereoscopic technique (Coherent Test System A 100). The results showed that there was statistical significance (P less than 0.01) in 6 parameters including Volume Density (Vv), Surface Density (Sv), Mean Diameter (D), Number Density (Nv) of nucleus and Mean Curvature Density (Kv) and Surface Curvature (K) of the gland, The new method of pathologic morphometry to differentiate adenoma from carcinoma was provided for clinical diagnosis. This method is more scientific, not only being different from the classical pathologic diagnosis, but also avoiding personal subjectivity. Colon adenoma was divided into two subtypes (A and B) according to the threshold of parameter. (Type A below the threshold and Type B above the threshold). Type A is well differentiated adenoma, but Type B tends towards malignancy. The higher the stereoscopic parameters, the higher the malignant tendency. Histologic parameters showed the objective index in pathologic diagnosis.
采用体视学技术（相干测试系统A 100）对10例正常黏膜、15例绒毛状腺瘤和20例结肠癌进行了定量分析。结果显示，包括腺泡的体积密度（Vv）、表面积密度（Sv）、平均直径（D）、核数密度（Nv）以及平均曲率密度（Kv）和表面曲率（K）在内的6项参数具有统计学意义（P＜0.01）。为临床诊断提供了一种鉴别腺瘤与癌的病理形态计量学新方法。该方法更为科学，既不同于经典病理诊断，又避免了个人主观性。根据参数阈值将结肠腺瘤分为两个亚型（A和B）（阈值以下为A型，阈值以上为B型）。A型为高分化腺瘤，而B型有恶变倾向。体视学参数越高，恶变倾向越高。组织学参数为病理诊断提供了客观指标。
