Kayser K K, Modlinger F, Postl K
Anal Quant Cytol Histol. 1985 Sep;7(3):205-12.
A general concept is presented for the analysis of histopathologically adenomatous structures at low levels of magnification. The algorithm is based upon structures of glands, not upon structures of single cells. Low microscopic magnification was used to assess the following parameters in colon mucosa: minimum diameter of glands, minimum distance to neighboring glands, number of neighbors, area of glands and circumference of glands. Twenty different specimens were analyzed for each of the following diagnostic groups: healthy tissue, tubulovillous adenoma and moderately to highly differentiated adenocarcinoma of the colon. Statistically significant differences (p less than or equal to 0.01) were obtained for each measured parameter for each group. The data indicate that low-resolution morphometry can be used successfully for the automatic separation of healthy, benign and malignant growths in adenomatous tissue.
提出了一种用于在低倍放大倍数下分析组织病理学腺瘤结构的一般概念。该算法基于腺体结构，而非单个细胞结构。使用低倍显微镜放大倍数来评估结肠黏膜中的以下参数：腺体的最小直径、到相邻腺体的最小距离、相邻腺体数量、腺体面积和腺体周长。对以下每个诊断组的二十个不同标本进行了分析：健康组织、管状绒毛状腺瘤和结肠中高度分化腺癌。对于每组的每个测量参数，均获得了具有统计学意义的差异（p小于或等于0.01）。数据表明，低分辨率形态测量法可成功用于腺瘤组织中健康、良性和恶性生长的自动分离。
