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澳大利亚儿童的致命急性中毒事件(2003 - 2013年)。

Fatal acute poisonings in Australian children (2003-13).

作者信息

Pilgrim Jennifer L, Jenkins Elizabeth L, Baber Yeliena, Caldicott David, Drummer Olaf H

机构信息

Department of Forensic Medicine, Monash University, Australia.

Deaths from Emergencies and Accidents Data Set (DEADSet) Project, Australia.

出版信息

Addiction. 2017 Apr;112(4):627-639. doi: 10.1111/add.13669. Epub 2016 Dec 7.

Abstract

BACKGROUND AND AIMS

Fatal poisonings in children comprise a small proportion of cases investigated by an Australian coroner; however, they present a major opportunity for death prevention. This study aimed to examine fatal child poisonings in Australia to (1) estimate the rate of acute poisoning deaths in children; (2) describe the key characteristics of the cohort; and (3) describe the outcomes of coronial recommendations made as a death prevention measure.

DESIGN

Retrospective case series.

SETTING

The National Coronial Information System (NCIS), a database of cases reported to an Australian coroner.

PARTICIPANTS

Ninety poisoning deaths reported to an Australian coroner between January 2003 and December 2013 involving children (≤ 16 years of age).

MEASURES

Logistic regression, Pearson's correlation coefficient and descriptive statistics were used to examine the significance of associations. The primary outcome measures were poisoning type and cause of death. Covariates included age and mental illness.

FINDINGS

There were marginally more males (52.2%) [confidence interval (CI) = 44.4-45.6] in the cohort and most occurred in the 13-16-year age group (58.9%) (CI = 7.5-12.5). Deaths were typically unintentional (61.1%) (CI = 17.9-27.1) and occurred in the home (68.9%) (CI = 6.8-15.7). The most common form of poisoning was due to opioids (24.4%), followed by carbon monoxide (20%) and volatile substances (18.9%) (CI = 18.5-19.6). Males had slightly higher odds of dying from prescription opioids compared with females [odds ratio (OR) = 1.9, CI = 0.7-5.1], but this was not statistically significant. A recommendation was made by a coroner in 12 cases, 10 of which related to poisons (including drugs). Of these, eight recommendations were implemented.

CONCLUSIONS

In Australia between 2003 and 2013 there were on average eight acute poisoning deaths in children each year, most commonly involving prescription opioids and adolescents. There has been a downward trend in mortality since 2003. These cases generated more than twice as many recommendations for public safety compared with other Australian coroners' cases.

摘要

背景与目的

儿童中毒致死病例在澳大利亚验尸官调查的案件中占比很小;然而,它们却是预防死亡的一个重要契机。本研究旨在调查澳大利亚儿童中毒致死情况,以(1)估计儿童急性中毒死亡率;(2)描述该队列的关键特征;(3)描述作为预防死亡措施提出的验尸官建议的结果。

设计

回顾性病例系列研究。

研究地点

国家验尸信息系统(NCIS),一个向澳大利亚验尸官报告的案件数据库。

研究对象

2003年1月至2013年12月期间向澳大利亚验尸官报告的90例涉及儿童(≤16岁)的中毒死亡病例。

测量方法

采用逻辑回归、皮尔逊相关系数和描述性统计来检验关联的显著性。主要结局指标为中毒类型和死因。协变量包括年龄和精神疾病。

研究结果

该队列中男性略多(52.2%)[置信区间(CI)=44.4 - 45.6],且大多数发生在13 - 16岁年龄组(58.9%)(CI = 7.5 - 12.5)。死亡通常为意外(61.1%)(CI = 17.9 - 27.1),且发生在家中(68.9%)(CI = 6.8 - 15.7)。最常见的中毒形式是阿片类药物中毒(24.4%),其次是一氧化碳中毒(20%)和挥发性物质中毒(18.9%)(CI = 18.5 - 19.6)。与女性相比,男性因处方阿片类药物死亡的几率略高[比值比(OR)=1.9,CI = 0.7 - 5.1],但无统计学意义。验尸官在12起案件中提出了建议,其中10起与毒物(包括药物)有关。其中,8条建议得到了落实。

结论

2003年至2013年期间,澳大利亚每年平均有8例儿童急性中毒死亡病例,最常见的涉及处方阿片类药物和青少年。自2003年以来死亡率呈下降趋势。与澳大利亚验尸官的其他案件相比,这些病例产生的公共安全建议数量多出两倍多。

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