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安大略省儿童阿片类药物死亡情况:一项全省范围的研究。

Opioid deaths in children in Ontario: A province-wide study.

作者信息

Assen Katrina, Urbantke Elizabeth, Wilson Michael, Rieder Michael

机构信息

Department of Paediatrics, Schulich School of Medicine & Dentistry, University of Western Ontario.

Office of the Chief Coroner of Ontario.

出版信息

Paediatr Child Health. 2024 Oct 10;30(3):122-125. doi: 10.1093/pch/pxae064. eCollection 2025 Jun.

Abstract

OBJECTIVES

Opioid-related deaths are an ongoing concern. There have been increasing numbers of fentanyl-related adult deaths with limited knowledge of the characteristics and circumstances of opioid toxicity deaths in children. Our aim was to address this using province-wide data capturing all deaths in children under the age of 10 years in Ontario.

METHODS

Data were extracted from the opioid investigative aid database at the Office of the Chief Coroner from the implementation of the system from October 1, 2017, to October 31, 2021. This collects all opioid-related deaths in Ontario (population 14.7 million). A chart review was undertaken on all deaths under 10 years of age. Patient characteristics were calculated as percentages; descriptive analysis was conducted.

RESULTS

Ten deaths in children under the age of 10 occurred during the study period. The average age was 1.9 years with the oldest being 4 years and 9 months. The causative opioid was fentanyl alone in four cases (40%), fentanyl and other drugs in four cases (40%), and hydromorphone and methadone in one case each (10%). Most cases involved improperly stored medication or illicit substances. All children who died had previous child protection service involvement, and at least 70% of their families had previous police involvement.

CONCLUSIONS

Fentanyl was the primary substance involved in 80% of deaths. Several potential areas of system change include education on fentanyl risk to young children, careful storage of illicit substances, and implications for how the child protection system intervenes in homes where the use of opioids and illicit substance use is reported to occur.

摘要

目的

与阿片类药物相关的死亡一直令人担忧。与芬太尼相关的成人死亡人数不断增加,而对儿童阿片类药物中毒死亡的特征和情况了解有限。我们的目标是利用安大略省全省范围内记录10岁以下儿童所有死亡情况的数据来解决这一问题。

方法

数据从首席验尸官办公室的阿片类药物调查援助数据库中提取,时间跨度为2017年10月1日系统实施至2021年10月31日。该数据库收集了安大略省(人口1470万)所有与阿片类药物相关的死亡情况。对所有10岁以下儿童的死亡病例进行了图表审查。患者特征以百分比计算;进行了描述性分析。

结果

研究期间有10名10岁以下儿童死亡。平均年龄为1.9岁,最大的为4岁9个月。致死的阿片类药物中,单独使用芬太尼的有4例(40%),芬太尼与其他药物联用的有4例(40%),氢吗啡酮和美沙酮各1例(10%)。大多数病例涉及药物储存不当或非法物质。所有死亡儿童此前都有儿童保护服务机构介入,且至少70%的家庭此前有警方介入。

结论

芬太尼是80%死亡病例中的主要涉事物质。系统变革的几个潜在领域包括对幼儿进行芬太尼风险教育、妥善储存非法物质,以及儿童保护系统对报告有阿片类药物和非法物质使用情况的家庭进行干预的影响。

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The impact of the prescription opioid epidemic on young children: Trends and mortality.处方类阿片流行对幼儿的影响:趋势和死亡率。
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