Veeravelli Suhitha, Najafi Bijan, Marin Ivan, Blumenkron Fernando, Smith Shannon, Klotz Stephen A
Department of Surgery, Interdisciplinary Consortium on Advanced Motion Performance (iCAMP), College of Medicine, University of Arizona.
Interdisciplinary Consortium on Advanced Motion Performance (iCAMP), Division of Vascular Surgery and Endovascular Therapy, Michael E. DeBakey Department of Surgery, Baylor College of Medicine.
J Vis Exp. 2016 Oct 6(116):54275. doi: 10.3791/54275.
Approximately 1.2 million people in the United States live with HIV infection. Medical advancements have increased the life expectancy and this cohort is aging. HIV-positive individuals have a high incidence of frailty (~20%) characterized by depression and sedentary behavior. Exercise would be healthy, but due to the frail status of many HIV-positive individuals, conventional exercise is too taxing. The aim of this study was to evaluate the effectiveness and acceptability of a novel game-based training program (exergame) in ameliorating some aspects of frailty in HIV-infected individuals. Ten older people living with HIV were enrolled in an exergame intervention. Patients performed balance exercises such as weight shifting, ankle reaching, and obstacle crossing. Real-time visual/audio lower-extremity joint motion feedback was provided using wearable sensors to assist feedback and encourage subjects to accurately execute each exercise task. Patients trained twice a week for 45 min for 6 weeks. Changes in balance, gait, psychosocial parameters and quality of life parameters were assessed at the beginning, midterm and at conclusion of the training program. Ten patients completed the study and their results analyzed. The mean age was 57.2 ± 9.2 years. The participants showed a significant reduction in center of mass sway (78.2%, p = .045) during the semi-tandem balance stance with eyes closed and showed a significant increase in gait speed during a dual task motor-cognitive assessment (9.3%, p = .048) with an increase in stride velocity of over 0.1 m/sec. A significant reduction in reported pain occurred (43.5%, p = .041). Preliminary results of this exergame intervention show promise in improving balance and mobility while requiring older people living with HIV to be more active. The exergame can be continued at home and may have long term as well as short-term benefits for ameliorating frailty associated with HIV infection.
美国约有120万人感染了艾滋病毒。医学进步提高了预期寿命，这一群体正在老龄化。艾滋病毒呈阳性的个体虚弱发生率很高（约20%），其特征为抑郁和久坐不动的行为。运动有益健康，但由于许多艾滋病毒呈阳性个体身体虚弱，传统运动负担过重。本研究的目的是评估一种新型的基于游戏的训练计划（健身游戏）在改善艾滋病毒感染者虚弱状况某些方面的有效性和可接受性。10名感染艾滋病毒的老年人参加了健身游戏干预。患者进行了诸如重心转移、脚踝伸展和跨越障碍物等平衡练习。使用可穿戴传感器提供实时视觉/音频下肢关节运动反馈，以辅助反馈并鼓励受试者准确执行每项运动任务。患者每周训练两次，每次45分钟，共训练6周。在训练计划开始、中期和结束时评估平衡、步态、心理社会参数和生活质量参数的变化。10名患者完成了研究并对结果进行了分析。平均年龄为57.2±9.2岁。参与者在闭眼半串联平衡姿势期间重心摆动显著减少（78.2%，p = 0.045），在双重任务运动认知评估期间步态速度显著增加（9.3%，p = 0.048），步幅速度增加超过0.1米/秒。报告的疼痛显著减轻（43.5%，p = 0.041）。这项健身游戏干预的初步结果显示，在改善平衡和活动能力方面有前景，同时要求感染艾滋病毒的老年人更加活跃。健身游戏可以在家中继续进行，可能对改善与艾滋病毒感染相关的虚弱状况有短期和长期益处。
