Rees Hilary Caitlyn, Meister Edward, Mohler Martha Jane, Klotz Stephen A
Department of Medicine, University of Arizona, Tucson, AZ, USA.
Arizona Center for Aging, University of Arizona.
J Int Assoc Provid AIDS Care. 2016 Mar-Apr;15(2):131-4. doi: 10.1177/2325957414553848. Epub 2014 Oct 15.
Frailty is common in HIV-infected patients, but its causes are elusive. We assessed 122 clinic patients for frailty using the 5-measure Fried Frailty criteria. The prevalence of frailty was 19% (n = 23) and all frail patients reported exhaustion with a Center for Epidemiologic Studies Depression Scale score >16 indicating depression. The next most common criterion was low physical activity (expenditure of kcal/week). Markers of sarcopenia such as decreased grip strength and decreased gait speed, hallmarks of frailty in the elderly, were the least common of the 5 criteria. Frailty was reversible: 6 frail patients returned for reassessment and only 2 were frail. We conclude that frailty in the HIV-infected patients is potentially reversible and strongly associated with depression and low physical activity, whereas frailty in the elderly is associated with aging-related sarcopenia and is often irreversible.
衰弱在感染HIV的患者中很常见，但其病因尚不清楚。我们使用五项弗里德衰弱标准对122名门诊患者进行了衰弱评估。衰弱的患病率为19%（n = 23），所有衰弱患者均报告有疲惫感，且流行病学研究中心抑郁量表评分>16表明存在抑郁。其次最常见的标准是体力活动水平低（每周千卡消耗量）。肌肉减少症的标志物，如握力下降和步态速度减慢，是老年人衰弱的标志，在五项标准中是最不常见的。衰弱是可逆的：6名衰弱患者回来重新评估，只有2名仍为衰弱状态。我们得出结论，感染HIV患者的衰弱可能是可逆的，且与抑郁和体力活动水平低密切相关，而老年人的衰弱与衰老相关的肌肉减少症有关，且通常是不可逆的。
