Guo Liang, Zheng Liqiang, Guo Xiaofan, Chang Ye, Zhou Xinghu, Sun Yingxian
1 Department of Cardiology, The First Hospital of China Medical University , Shenyang, People's Republic of China .
2 Department of Clinical Epidemiology, Shengjing Hospital of China Medical University , Shenyang, People's Republic of China .
Genet Test Mol Biomarkers. 2016 Dec;20(12):766-770. doi: 10.1089/gtmb.2016.0125. Epub 2016 Oct 21.
Complement component 5 (C5) has been described to play an important role in the development and progression of atherosclerosis and cardiovascular disease. Our aim was to determine whether genetic variation of C5 was associated with ischemic stroke (IS) in northeast Chinese population.
We used a case-control study involving 386 IS patients and 386 non-IS controls from a rural population and determined the genotypes of five polymorphisms (rs12237774, rs17611, rs4837805, rs7026551, and rs1017119) of C5 gene by Snapshot single-nucleotide polymorphism genotyping assays to assess any links with IS.
In univariate analysis, rs17611 was significantly associated with IS in the additive model, the dominant model, and recessive model (additive p 0.031, dominant p 0.034, and recessive p 0.027). After adjustment for Binary Logistic Regression, rs17611 polymorphism was still significant in three models (adjusted odds ratio (OR) = 1.306, 95% confidence interval (CI) = 1.069-1.595, p-value = 0.009 in an additive model; OR = 1.378, 95% CI = 1.024-1.856, p-value = 0.035 in a dominant model; and OR = 1.511, 95% CI = 1.048-2.18, p-value = 0.027 in a recessive model).
In this sample of patients, genetic variation of rs17611 in C5 is associated with higher prevalence of IS.
补体成分5（C5）已被描述为在动脉粥样硬化和心血管疾病的发生发展中起重要作用。我们的目的是确定C5基因变异是否与中国东北人群的缺血性中风（IS）相关。
我们采用病例对照研究，纳入了来自农村人群的386例IS患者和386例非IS对照，并通过Snapshot单核苷酸多态性基因分型检测确定C5基因的五个多态性（rs12237774、rs17611、rs4837805、rs7026551和rs1017119）的基因型，以评估与IS的任何关联。
在单因素分析中，rs17611在加性模型、显性模型和隐性模型中与IS显著相关（加性模型p = 0.031，显性模型p = 0.034，隐性模型p = 0.027）。经二元逻辑回归调整后，rs17611多态性在三个模型中仍具有显著性（加性模型中调整后的比值比（OR）= 1.306，95%置信区间（CI）= 1.069 - 1.595，p值 = 0.009；显性模型中OR = 1.378，95% CI = 1.024 - 1.856，p值 = 0.035；隐性模型中OR = 1.511，95% CI = 1.048 - 2.18，p值 = 0.027）。
在该患者样本中，C5基因中rs17611的基因变异与IS的较高患病率相关。
