Kongerud J, Søyseth V, Johansen B
Dept of Thoracic Medicine, National Hospital of Norway, University Hospital, Rikshospitalet, Oslo.
Eur Respir J. 1989 Jul;2(7):681-4.
Standardization of the solute output from the Wright nebulizer is necessary in nonspecific bronchial challenge to obtain reproducible results. Airflow and driving pressure are known determinants of the output. In an epidemiological study, in which day-to-day variations in room temperature occurred, we found the reproducibility of the output from a Wright nebulizer to be outside the range of acceptance. We have, therefore, examined to what extent ambient temperature and humidity might influence the output from three Wright nebulizers. The solute output was linearly correlated not only to flow (r = 0.98) and driving pressure (r = 0.90) but also to room temperature (r = 0.96). The mean output increased approximately 23% when room temperature was increased from 19 to 24 degrees C. This is equivalent to an increase in airflow of more than one litre. Ambient humidity did not influence the nebulizer output. When temperature was included in the calibration procedure, the coefficient of variation of the output decreased from 5 to 2%. This emphasizes the need for calibration of the Wright nebulizer with regard to ambient temperature as well as to airflow and pressure, especially in epidemiological field studies in which large variations of temperature are likely to occur.
在非特异性支气管激发试验中，对赖特雾化器的溶质输出进行标准化对于获得可重复的结果是必要的。气流和驱动压力是已知的输出决定因素。在一项流行病学研究中，室温存在每日变化，我们发现赖特雾化器输出的可重复性超出了可接受范围。因此，我们研究了环境温度和湿度可能在多大程度上影响三台赖特雾化器的输出。溶质输出不仅与流量（r = 0.98）和驱动压力（r = 0.90）呈线性相关，还与室温（r = 0.96）呈线性相关。当室温从19摄氏度升高到24摄氏度时，平均输出增加了约23%。这相当于气流增加了一升以上。环境湿度不影响雾化器输出。在校准程序中纳入温度后，输出的变异系数从5%降至2%。这强调了对赖特雾化器进行环境温度以及气流和压力校准的必要性，特别是在可能出现较大温度变化的流行病学现场研究中。
