Cockcroft D W, Hurst T S, Gore B P
Department of Medicine, University of Saskatchewan, Saskatoon, Canada.
Chest. 1989 Sep;96(3):505-8. doi: 10.1378/chest.96.3.505.
Evaporative water losses from jet nebulizers produce temperature drop, reduction in total nebulizer output with increased nebulization time, and increasing concentration of solute remaining in the nebulizer. These were documented and quantitated for the Wright nebulizer which is used for one histamine/methacholine inhalation test method. Indirect determination of nebulizer aerosol output, made by estimation of total sodium lost from the nebulizer, was about 25 percent of total output as determined by weight change. A similar tendency was seen for a De Vilbiss 40 nebulizer for both reduction in total nebulizer output with increasing duration of nebulization, and increased solute concentration remaining in the nebulizer. These data must be taken into account when standardizing inhalation provocation tests. Nebulizers should be calibrated under the same conditions that they are used during the test. Histamine and methacholine solutions should be discarded after a single use in the 2-min tidal breathing Wright nebulizer method.
喷射式雾化器的蒸发水损失会导致温度下降、随着雾化时间增加雾化器总输出量减少以及雾化器中溶质浓度增加。这些情况已针对用于一种组胺/乙酰甲胆碱吸入试验方法的赖特雾化器进行了记录和定量分析。通过估算雾化器中损失的总钠量间接测定雾化器气溶胶输出量，该值约为通过重量变化测定的总输出量的25%。对于德维比斯40型雾化器，随着雾化持续时间增加，雾化器总输出量减少以及雾化器中剩余溶质浓度增加，也观察到了类似趋势。在标准化吸入激发试验时必须考虑这些数据。雾化器应在与试验期间使用条件相同的情况下进行校准。在采用2分钟潮气呼吸赖特雾化器法时，组胺和乙酰甲胆碱溶液单次使用后应丢弃。
