Romani S, Campuzano S, Macagno E R, Modolell J
Centro de Biología Molecular, Consejo Superior de Investigaciones Científicas, Madrid, Spain.
Genes Dev. 1989 Jul;3(7):997-1007. doi: 10.1101/gad.3.7.997.
Several kinds of sensory organs (SOs) appear in stereotyped positions on the adult Drosophila cuticle. The generation of these SOs requires the activity of the achaete (ac) and scute (sc) genes. To investigate whether ac and sc also provide spatial information for the positioning of SOs, we have analyzed the patterns of expression of these genes in the wing imaginal disc around the time that SO precursors are being specified. We find that expression coincides with and is restricted to areas of the disc where these precursors are known to be located. In the loss-of-function sc mutant, sc RNA is depleted in a single area located in the region where the precursor for the suppressed macrochaeta should be found. Moreover, some, and probably all, SOs require expression of these genes to reach the earliest detectable differentiated state. These and other results presented here, together with the finding that expansion of the areas of ac and/or sc expression causes the development of ectopic SOs, indicate that ac and sc promote the determination of SO precursors and delimit the regions of the imaginal discs where they can develop.
几种感觉器官（SOs）在成年果蝇的表皮上以固定的位置出现。这些感觉器官的生成需要achaete（ac）和scute（sc）基因的活性。为了研究ac和sc是否也为感觉器官的定位提供空间信息，我们分析了在感觉器官前体被指定时翅成虫盘内这些基因的表达模式。我们发现，表达与已知这些前体所在的盘区重合且局限于这些区域。在功能缺失的sc突变体中，sc RNA在位于应发现被抑制的大刚毛前体的区域内的单个区域中耗尽。此外，一些，可能所有的感觉器官都需要这些基因的表达才能达到最早可检测到的分化状态。这里呈现的这些及其他结果，连同ac和/或sc表达区域的扩展会导致异位感觉器官发育这一发现，表明ac和sc促进感觉器官前体的确定，并划定成虫盘中它们能够发育的区域。
