Milošević Nataša, Jakšić Vladimir, Sudji Jan, Vuković Bojan, Ičin Tijana, Milić Nataša, Medić Stojanoska Milica
a Faculty of Medicine, Department of Pharmacy , University of Novi Sad , Novi Sad , Serbia.
b Faculty of Medicine , University of Novi Sad , Novi Sad , Serbia.
Int J Environ Health Res. 2017 Feb;27(1):11-26. doi: 10.1080/09603123.2016.1246654. Epub 2016 Oct 24.
Bisphenol A (BPA) is a ubiquitous environmental pollutant which is often associated with various health issues. In this study 103 healthy female volunteers in reproductive age from Serbian north province Vojvodina were enrolled and examined for the BPA exposure in the urine samples after 12 h of fasting. BPA was found in 35.92 % (37/103) of subjects. Statistically significant increment in waist circumference (p = 0.045) and waist-to-height ratio (p = 0.037) was observed among the BPA positive women in comparison with the women who had the same energetic balance and had not been exposed to BPA. Linear correlation was obtained between the BPA concentration in urine samples and body mass index (r = 0.35, p = 0.003) waist circumference (r = 0.21, p = 0.02) and waist-to-height ratio (r = 0.25, p = 0.01) among the obese. High energetic intake and reduced physical activity additionally pronounced BPA positive association with obesity. No statistically significant difference was observed in triglycerides, HDL and LDL cholesterol levels between the BPA exposed and BPA non-exposed female volunteers.
双酚A（BPA）是一种普遍存在的环境污染物，常与各种健康问题相关。在本研究中，招募了塞尔维亚北部伏伊伏丁那省103名育龄健康女性志愿者，在禁食12小时后检测她们尿液样本中的双酚A暴露情况。在35.92%（37/103）的受试者中发现了双酚A。与能量平衡相同且未接触双酚A的女性相比，双酚A阳性女性的腰围（p = 0.045）和腰高比（p = 0.037）有统计学意义的增加。在肥胖者中，尿液样本中的双酚A浓度与体重指数（r = 0.35，p = 0.003）、腰围（r = 0.21，p = 0.02）和腰高比（r = 0.25，p = 0.01）之间存在线性相关性。高能量摄入和体力活动减少进一步加剧了双酚A与肥胖的正相关。在接触双酚A和未接触双酚A的女性志愿者之间，甘油三酯、高密度脂蛋白和低密度脂蛋白胆固醇水平没有观察到统计学显著差异。
