Milošević Nataša, Milić Nataša, Živanović Bosić Dragana, Bajkin Ivana, Perčić Ivanka, Abenavoli Ludovico, Medić Stojanoska Milica
Department of Pharmacy, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, Novi Sad, Serbia.
Health Center Ruma, Ruma, Serbia.
Environ Monit Assess. 2017 Dec 13;190(1):17. doi: 10.1007/s10661-017-6398-0.
Phthalates are ubiquitous environmental contaminants, massively used in industry as plasticizers and additives in cosmetics, which may impair the human endocrine system inducing fertility problems, respiratory diseases, obesity, and neuropsychological disorders. The aim of this study was to examine the influence of the monoethyl phthalate (MEP) and mono-(2-ethylhexyl) phthalate (MEHP) on the liver function and cardiometabolic risk factors in males. In this research, 102 male participants (51 normal weight and 51 overweight/obese) were enrolled and examined for phthalate metabolites exposure in urine samples after 12 h of fasting. MEP was found in 28.43% (29/102) volunteers, while MEHP was detected among 20.59% (21/102) participants. Statistically significant increment in transaminase serum levels was observed in MEP-positive normal weight subgroup. Linear correlation was obtained between MEP concentration in urine samples and triglyceride (TG) serum levels (r = 0.33; p < 0.01), visceral adiposity index (VAI) (r = 0.41; p < 0.01), lipid accumulation product (LAP) (r = 0.32; p < 0.01), and TG to high-density lipoprotein (HDL) ratio (r = 0.40, p < 0.01) among the obese. The MEHP-positive normal weight volunteers had statistically significant increment of body mass index (p = 0.03) compared to MEHP-negative participants. Urine MEHP concentrations were negatively correlated with HDL serum levels (r = 0.31; p < 0.05) in the normal weight subgroup. The phthalates exposure may be related to statistically significant ALT and AST serum levels increment as well as with increased BMI, while the phthalate levels in the urine may be correlated with increased TG and decreased HDL cholesterol serum levels and associated with indicators of cardiometabolic risk and insulin resistance as LAP and VAI.
邻苯二甲酸盐是普遍存在的环境污染物，在工业中大量用作增塑剂以及化妆品中的添加剂，可能会损害人体内分泌系统，引发生育问题、呼吸系统疾病、肥胖症和神经心理障碍。本研究的目的是检测邻苯二甲酸单乙酯（MEP）和邻苯二甲酸单（2-乙基己基）酯（MEHP）对男性肝功能和心脏代谢风险因素的影响。在这项研究中，招募了102名男性参与者（51名体重正常者和51名超重/肥胖者），并在禁食12小时后检测他们尿液样本中邻苯二甲酸酯代谢物的暴露情况。在28.43%（29/102）的志愿者中检测到了MEP，而在20.59%（21/102）的参与者中检测到了MEHP。在MEP呈阳性的体重正常亚组中，观察到血清转氨酶水平有统计学意义的升高。在肥胖者中，尿液样本中MEP浓度与血清甘油三酯（TG）水平（r = 0.33；p < 0.01）、内脏脂肪指数（VAI）（r = 0.41；p < 0.01）、脂质蓄积产物（LAP）（r = 0.32；p < 0.01）以及TG与高密度脂蛋白（HDL）比值（r = 0.40，p < 0.01）之间存在线性相关性。与MEHP呈阴性的参与者相比，MEHP呈阳性的体重正常志愿者的体重指数有统计学意义的升高（p = 0.03）。在体重正常亚组中，尿液MEHP浓度与血清HDL水平呈负相关（r = 0.31；p < 0.05）。邻苯二甲酸盐暴露可能与血清ALT和AST水平有统计学意义的升高以及BMI增加有关，而尿液中的邻苯二甲酸盐水平可能与TG升高、HDL胆固醇血清水平降低以及与心脏代谢风险和胰岛素抵抗指标如LAP和VAI有关。
