Sabherwal Sophie, English Jane A, Föcking Melanie, Cagney Gerard, Cotter David R
a Department of Psychiatry, Royal College of Surgeons in Ireland , ERC Beaumont Hospital , Dublin , Ireland.
b Proteome Research Centre, UCD Conway Institute of Biomolecular and Biomedical Research, School of Medicine, and Medical Sciences , University College Dublin , Dublin , Ireland.
Expert Rev Proteomics. 2016 Dec;13(12):1141-1155. doi: 10.1080/14789450.2016.1252262. Epub 2016 Nov 11.
Recent evidence supports an association between systemic abnormalities and the pathology of psychotic disorders which has led to the search for peripheral blood-based biomarkers. Areas covered: Here, we summarize blood biomarker findings in schizophrenia from the literature identified by two methods currently driving biomarker discovery in the human proteome; mass spectrometry and multiplex immunoassay. From a total of 14 studies in the serum or plasma of drug-free schizophrenia patients; 47 proteins were found to be significantly altered twice or more, in the same direction. Pathway analysis was performed on these proteins, and the resulting pathways discussed in relation to schizophrenia pathology. Future directions are also discussed, with particular emphasis on the potential for high-throughput validation techniques such as data-independent analysis for confirmation of biomarker candidates. Expert commentary: We present promising findings that point to a convergence of pathophysiological mechanisms in schizophrenia that involve the acute-phase response, glucocorticoid receptor signalling, coagulation, and lipid and glucose metabolism.
近期证据支持全身性异常与精神障碍病理学之间存在关联，这促使人们寻找基于外周血的生物标志物。涵盖领域：在此，我们总结了通过目前推动人类蛋白质组生物标志物发现的两种方法（质谱分析和多重免疫测定）从文献中确定的精神分裂症血液生物标志物研究结果。在总共14项针对未服用药物的精神分裂症患者血清或血浆的研究中，发现47种蛋白质在相同方向上有两次或更多次的显著变化。对这些蛋白质进行了通路分析，并讨论了所得通路与精神分裂症病理学的关系。还讨论了未来的方向，特别强调了高通量验证技术（如数据非依赖分析）用于确认生物标志物候选物的潜力。专家评论：我们展示了有前景的研究结果，这些结果表明精神分裂症的病理生理机制存在趋同，涉及急性期反应、糖皮质激素受体信号传导、凝血以及脂质和葡萄糖代谢。
