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用于将核酸递送至中枢神经系统(CNS)的纳米材料。

Nanomaterials for delivery of nucleic acid to the central nervous system (CNS).

作者信息

Wang Danyang, Wu Lin-Ping

机构信息

Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark; Guangzhou RiboBio Co., Ltd., Guangzhou 510663, China.

出版信息

Mater Sci Eng C Mater Biol Appl. 2017 Jan 1;70(Pt 2):1039-1046. doi: 10.1016/j.msec.2016.04.011. Epub 2016 Apr 11.

Abstract

Billions of dollars have been invested in the therapeutic application of nucleic acid-based agents in humans in recent years. There are inspirable data from ongoing clinical trial for different diseases. However, in order to widely apply nucleic acid in prevention, diagnosis and treatment of age-related disease, such as neurodegeneration and disorders, suitable, safe and effective drug delivery nanocarriers have to been developed to overcome the blood brain barrier (BBB), which is the most inflexible barrier in human body. Here, we highlight the structure and function of barriers in the central nervous system (CNS) and summary several types of nanomaterials which can be potentially used in the brain delivery nucleic acid.

摘要

近年来,已投入数十亿美元用于基于核酸的药物在人类治疗中的应用。目前针对不同疾病的临床试验有鼓舞人心的数据。然而,为了将核酸广泛应用于预防、诊断和治疗与年龄相关的疾病,如神经退行性疾病和功能障碍,必须开发合适、安全且有效的药物递送纳米载体,以克服血脑屏障(BBB),这是人体中最难以穿透的屏障。在此,我们重点介绍中枢神经系统(CNS)中屏障的结构和功能,并总结几种可能用于脑部核酸递送的纳米材料类型。

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