Liu Guangliang, McEnnis Kathleen
Otto H. York Department of Chemical and Materials Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA.
Polymers (Basel). 2022 Feb 28;14(5):993. doi: 10.3390/polym14050993.
Over recent decades, poly(lactic-co-glycolic acid) (PLGA) based nano- and micro- drug delivery vehicles have been rapidly developed since PLGA was approved by the Food and Drug Administration (FDA). Common factors that influence PLGA particle properties have been extensively studied by researchers, such as particle size, polydispersity index (PDI), surface morphology, zeta potential, and drug loading efficiency. These properties have all been found to be key factors for determining the drug release kinetics of the drug delivery particles. For drug delivery applications the drug release behavior is a critical property, and PLGA drug delivery systems are still plagued with the issue of burst release when a large portion of the drug is suddenly released from the particle rather than the controlled release the particles are designed for. Other properties of the particles can play a role in the drug release behavior, such as the glass transition temperature (). The , however, is an underreported property of current PLGA based drug delivery systems. This review summarizes the basic knowledge of the glass transition temperature in PLGA particles, the factors that influence the , the effect of on drug release behavior, and presents the recent awareness of the influence of on drug delivery applications.
在最近几十年里，自从聚乳酸-乙醇酸共聚物（PLGA）被美国食品药品监督管理局（FDA）批准以来，基于PLGA的纳米和微米级药物递送载体得到了迅速发展。研究人员已经广泛研究了影响PLGA颗粒性质的常见因素，如粒径、多分散指数（PDI）、表面形态、zeta电位和载药效率。这些性质都被发现是决定药物递送颗粒药物释放动力学的关键因素。对于药物递送应用而言，药物释放行为是一个关键性质，并且当大部分药物从颗粒中突然释放而不是按照颗粒设计的控释方式释放时，PLGA药物递送系统仍然受到突释问题的困扰。颗粒的其他性质也会在药物释放行为中发挥作用，比如玻璃化转变温度（）。然而，在当前基于PLGA的药物递送系统中，玻璃化转变温度是一个报道较少的性质。本综述总结了PLGA颗粒中玻璃化转变温度的基本知识、影响玻璃化转变温度的因素、玻璃化转变温度对药物释放行为的影响，并介绍了最近对玻璃化转变温度对药物递送应用影响的认识。
Zotero 插件
