帕金森病痴呆患者血浆神经酰胺与认知及神经精神表现之间的关联
Associations between plasma ceramides and cognitive and neuropsychiatric manifestations in Parkinson's disease dementia.
作者信息
Xing Yi, Tang Yi, Zhao Lina, Wang Qi, Qin Wei, Ji Xiaojuan, Zhang Jinlan, Jia Jianping
机构信息
Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China.
Department of Cadre Health Care, Beijing Jishuitan Hospital, Beijing, China.
出版信息
J Neurol Sci. 2016 Nov 15;370:82-87. doi: 10.1016/j.jns.2016.09.028. Epub 2016 Sep 19.
BACKGROUND
The abnormal metabolism of ceramides may account for the pathogenesis of Parkinson's disease dementia (PDD). However, the effect of ceramides on cognitive domain impairments and neuropsychiatric symptoms of PDD remains unknown.
METHODS
A total of 38 PDD, 40 PD with no cognitive impairment (PD-NC) and 40 normal controls were included. A series of cognitive tests and the Neuropsychiatric Inventory (NPI) were used to assess cognitive domains and neuropsychiatric symptoms. A non-fasting blood sample was obtained from each subject. Plasma ceramide levels were tested by HPLC-MS/MS analysis.
RESULTS
C14:0 and C24:1 levels were significantly higher in PDD than in PD-NC and normal controls. Verbal memory was negatively correlated with C14:0 and C24:1. After controlling for confounding factors, C22:0, C20:0 and C18:0 were significantly associated with hallucinations, anxiety and sleep behavior disturbances, respectively.
CONCLUSION
In PDD, the increase in ceramide levels was correlated with decreased memory function and associated with higher odds of multiple neuropsychiatric symptoms.
背景
神经酰胺的代谢异常可能是帕金森病痴呆（PDD）发病机制的原因。然而，神经酰胺对PDD认知领域损害和神经精神症状的影响仍不清楚。
方法
共纳入38例PDD患者、40例无认知障碍的帕金森病（PD-NC）患者和40名正常对照者。采用一系列认知测试和神经精神科问卷（NPI）评估认知领域和神经精神症状。采集每位受试者的非空腹血样。通过高效液相色谱-串联质谱（HPLC-MS/MS）分析检测血浆神经酰胺水平。
结果
PDD患者的C14:0和C24:1水平显著高于PD-NC患者和正常对照者。言语记忆与C14:0和C24:1呈负相关。在控制混杂因素后，C22:0、C20:0和C18:0分别与幻觉、焦虑和睡眠行为障碍显著相关。
结论
在PDD中，神经酰胺水平升高与记忆功能下降相关，并与多种神经精神症状的较高发生率相关。
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